Actively Recruiting
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Led by University of Washington · Updated on 2025-08-29
90
Participants Needed
2
Research Sites
199 weeks
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
CONDITIONS
Official Title
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI 30.0 - 50.0 kg/m2
- Able to attend study intervention classes and study visits/assessments
- Independently living with access to food preparation facilities
You will not qualify if you...
- Current smoker or regular use of nicotine containing products and/or cannabis
- Heavy alcohol use (≥2 drinks/day for females, ≥3 drinks/day for males) or drug use
- Known cognitive impairments or history of stroke
- Type 2 diabetes (known diagnosis or A1c ≥6.5%)
- Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
- Females currently pregnant, breastfeeding, or within 6 months postpartum of full-term pregnancy
- Use of medications affecting appetite or chronic anticoagulant use
- History of bariatric surgery
- History of eating disorder
- Current participation in a formal weight loss program
- Prior or current participation in weight loss research studies
- Weight reduced by more than 10% within past year
- Weight over 330 pounds (MRI limit)
- Allergy or unwillingness to consume study foods
- MRI contraindications (e.g., implanted metal, claustrophobia)
- Lack of compatible phone or access to videoconferencing for intervention
- Any condition deemed unsafe for participation by study team and principal investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Fred Hutch Cancer Center
Seattle, Washington, United States, 98109
Not Yet Recruiting
2
University of Washington - South Lake Union
Seattle, Washington, United States, 98109
Actively Recruiting
Research Team
A
ADAPT Study
CONTACT
A
ADAPT Study
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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