Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07193914

Adaptation of the ECCCLORE Program for Patients With Addictive and Traumatic Problems

Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2026-01-28

30

Participants Needed

1

Research Sites

69 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Complex posttraumatic stress disorder (cPTSD) is characterized by chronic and pervasive disruptions in emotion regulation, identity, and relationships following prolonged or multiple exposures to trauma. It is frequently found in patients with addiction. Individuals with cPTSD have more severe addiction. In addition, the co-occurrence of these two disorders is often associated with certain transdiagnostic processes such as impulsivity. Indeed, PTSD is linked to a higher impulsivity score, which in turn promotes increased substance use. A second process also associated with trauma and addiction is hostile attribution bias. Thus, the trauma-addiction comorbidity generates multiple behavioral consequences (aggression, increased substance use, etc.) that impact patients' quality of life and represent an important treatment target. Many authors and clinicians have worked on creating treatment programs targeting both disorders, although group format treatment lacks empirical support. Indeed, even though the Seeking Safety program has been shown to be effective in reducing PTSD symptoms and substance use, there is currently no evidence to suggest its superiority. The ECCCLORE program is a new 6-month cognitive behavioral therapy protocol initially designed for patients with borderline personality disorder, in whom addictive and traumatic issues are common. It is shorter than the standard dialectical behavioral therapy (DBT) program, which focuses on emotional dysregulation, impulsivity, and the traumatic dimension and lasts at least 1 year. It also integrates techniques from other approaches such as Acceptance and Commitment Therapy (ACT), which promotes the acceptance of internal experiences and engagement in actions consistent with values. It notably contains tools for developing emotional, distress tolerance, and interpersonal skills that could adapt to the difficulties generated by trauma and addiction. The objective of this research is to test the feasibility and acceptability of a 12-week ECCCLORE program adapted for patients with addictive and traumatic problems. The study investigators hypothesize that the implementation of this program will demonstrate satisfactory feasibility and acceptability.

CONDITIONS

Official Title

Adaptation of the ECCCLORE Program for Patients With Addictive and Traumatic Problems

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with one or more addictions
  • ASSIST questionnaire score greater than or equal to 11 for alcohol consumption and greater than or equal to 4 for other substances
  • Diagnosis of PTSD and/or CPTSD assessed using the ITQ scale
  • Ability to understand, write, and read French
  • The patient must have given their free and informed consent
  • The patient must be a member or beneficiary of a health insurance plan
Not Eligible

You will not qualify if you...

  • Participation in an interventional study involving a drug, medical device, or Category 1 study within 3 months prior to inclusion
  • Under safeguard of justice or state guardianship
  • Diagnosis of a psychotic disorder
  • Severe cognitive impairment (MoCA < 10)
  • Experiencing a manic or hypomanic episode
  • Experiencing a major depressive episode
  • Pregnant, parturient, or breastfeeding woman

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

CHU de Nîmes

Nîmes, Nîmes, France, 30029

Actively Recruiting

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Research Team

L

Laure Thebault

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

1

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Adaptation of the ECCCLORE Program for Patients With Addictive and Traumatic Problems | DecenTrialz