Actively Recruiting
Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study
Led by MedtronicNeuro · Updated on 2026-03-11
62
Participants Needed
5
Research Sites
110 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the effectiveness of the Medtronic Adaptive DBS therapy (aDBS) for Parkinson's Disease in China with the Percept family of Implantable Neurostimulators (Percept PC and Percept RC).
CONDITIONS
Official Title
Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject has idiopathic Parkinson's disease
- Subject is implanted with Percept PC or Percept RC and Medtronic DBS leads bilaterally in the same target (STN or GPi) at least 3 months ago for new implants or 1 month ago for replacements
- Subject responds to DBS therapy as judged by investigator
- DBS parameters and Parkinson's medications have been stable for at least 4 weeks and expected to remain stable through study
- Subject is configured to monopolar or dual monopolar stimulation using specified contacts on at least one side
- Subject is willing and able to attend all study visits and complete procedures
- Subject or legal representative can understand and provide informed consent
- Subject is male or non-pregnant female; females of child-bearing potential must use acceptable birth control
- Subject meets LFP screening criterion with Alpha-Beta band amplitude ≥ 1.2 µVp on specified DBS sensing channels
You will not qualify if you...
- Subject or caregiver unable to use patient programmer
- Subject has more than one lead in each brain hemisphere
- Subject has cortical leads or unapproved brain hardware
- Subject has more than one implantable neurostimulator (INS)
- INS battery life predicted to be less than 1 year at enrollment
- Beck Depression Inventory II score greater than 25
- Subject requires diathermy, transcranial magnetic stimulation, or electroconvulsive therapy
- Subject has metallic implants in the head (e.g., aneurysm clip, cochlear implant)
- Subject has or plans to receive other implanted electrical stimulation devices or medication pumps for Parkinson's
- Subject has abnormal neurological exam precluding participation
- Subject is breastfeeding
- Subject is under 18 years old
- Subject is currently or plans to participate in conflicting drug or device studies
- Subjects with signal artifact on all 6 aDBS sense pathways preventing threshold setting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Xuanwu Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
2
Sun Yat-sen Hospital
Guangzhou, Guangdong, China
Actively Recruiting
3
Huashan Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
4
Ruijin Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
5
West China Hospital
Chengdu, Sichuan, China
Actively Recruiting
Research Team
J
Jane Zhang, Principle Clinical Research Specialist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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