Actively Recruiting
Adaptive Dengue Antiviral Platform Trial
Led by Oxford University Clinical Research Unit, Vietnam · Updated on 2026-04-30
500
Participants Needed
2
Research Sites
245 weeks
Total Duration
On this page
Sponsors
O
Oxford University Clinical Research Unit, Vietnam
Lead Sponsor
H
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized, open-label adaptive platform trial aiming to screen the antiviral effectiveness of the experimental drug(s) in early dengue infection * Primary objectives: * To determine the antiviral effectiveness of the experimental drug(s) in early dengue infection * To assess the safety and tolerability of the experimental drug(s) in dengue patients * Secondary objective: * To assess the effect of the experimental drug(s) in dengue patients on physiological, clinical and virological parameters
CONDITIONS
Official Title
Adaptive Dengue Antiviral Platform Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female or male patients with clinical diagnosis of dengue virus infection and less than 48 hours of fever
- Positive NS1 rapid diagnostic test
- Age 10 years or older (depending on therapeutic license, may require 18+ years)
- Able to provide written informed consent or assent
- Agree to stay in hospital for intervention duration (usually 5 days) and attend follow-up visits at 30 and 60 days post enrollment
You will not qualify if you...
- Severe dengue at baseline including shock, respiratory distress, severe bleeding, or organ involvement (AST/ALT >1000 U/L, impaired consciousness, multiple organ dysfunction)
- Pregnancy or breastfeeding
- Signs of alternative diagnoses such as pneumonia or sepsis
- Renal failure with baseline eGFR <30 ml/min
- History or presence of significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, neuropsychiatric, autoimmune, dermatologic or immunosuppressive disorders
- Allergic disease or known hypersensitivity to study product components (mild non-medication allergies allowed)
- Any condition that may complicate study participation or participant well-being
- Participation in another investigational drug study within the past month
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Universiti Malaya Medical Centre
Kuala Lumpur, Malaysia, 59100
Not Yet Recruiting
2
Hospital for Tropical Diseases, Ho Chi Minh city
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
Research Team
S
Sophie Yacoub, MD., PhD.
CONTACT
C
Clinical Trials Unit Oxford University Clinical Research Unit
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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