Actively Recruiting
Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
Led by RAND · Updated on 2026-02-19
500
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
Sponsors
R
RAND
Lead Sponsor
A
Arrowhead Regional Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating adaptive interventions to increase long-term use of buprenorphine in adults with probable opioid use disorder (OUD) who come to the emergency department (ED). This trial uses a two-stage, sequential multiple assignment randomized design to develop the most effective approach. The study aims to compare different treatment strategies to see which helps maintain buprenorphine use longer and delays overdose, self-harm, or death. The trial includes several treatment options. Initially, participants receive either the CA Bridge Model with Substance Use Navigator (SUN) assisted treatment initiation and linkage to care or the same approach plus immediate telehealth connection to an outpatient provider (SUN+TeleBridge). Those who do not respond within 90 days are randomized to receive ongoing buprenorphine treatment by an ED-based interim treatment team (ED-ITT) alone or with added behavioral health support (ED-ITT+BHS) for up to 3 months. Responders receive no further active intervention unless they return to the ED or report stopping buprenorphine. Participants will be monitored for buprenorphine prescription fills over 6 months and tracked for overdose, suicide, self-harm, or death events. Researchers will review prescription records, patient reports, and ED visits to assess treatment adherence and outcomes. The study involves regular follow-up and behavioral health assessments to evaluate the effectiveness of different adaptive treatment strategies over one year.
CONDITIONS
Brief Title
Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presented for emergency department care at ARMC
- Age 18 or older
- Probable opioid use disorder diagnosis
- Speak and understand English or Spanish
- Have the capacity to give informed consent
- Provide a signed and dated informed consent form
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 90 days
Participants begin treatment with either SUN-assisted buprenorphine initiation and linkage to care or SUN plus immediate telehealth connection to an outpatient provider. Depending on response within 90 days, participants may continue initial treatment without active follow-up or proceed to a second stage intervention if non-responsive.
Participants engage with treatment visits and follow-up as needed during this period
Duration - Up to 3 months after initial 90 days
Non-responders receive ongoing buprenorphine treatment by an ED-based interim treatment team, with or without additional behavioral health support, for up to 3 months following initial treatment period.
Weekly visits for up to 12 weeks
Duration - Up to 6 months from enrollment
Participants are monitored for outcomes including buprenorphine use, overdose, self-harm, and death for up to 6 months from enrollment.
Ongoing assessments during follow-up period
Trial Site Locations
Total: 1 location
1
Arrowhead Regional Medical Center
Colton, California, United States, 92324
Actively Recruiting
Research Team
M
Mariah Kalmin, PhD
P
P'trice Jones, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
6
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