Actively Recruiting
Adaptive Mechanisms In GRown up ObeSity Study (AMIGROS)
Led by Vastra Gotaland Region · Updated on 2023-10-04
45
Participants Needed
1
Research Sites
295 weeks
Total Duration
On this page
Sponsors
V
Vastra Gotaland Region
Lead Sponsor
G
Göteborg University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes. Further, the molecules that induce insulin release in the fasting state when blood glucose is normal remain elusive. It is possible that galectin-1 is involved in adaptive mechanisms in adipose tissue in obese subjects.
CONDITIONS
Official Title
Adaptive Mechanisms In GRown up ObeSity Study (AMIGROS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 40 to 70 years
- BMI 18.0 to 25.0 kg/m2 for lean subjects and BMI 30.0 to 38.0 kg/m2 for obese insulin-sensitive and insulin-resistant subjects
- Fasting insulin less than 9.0 mU/l for lean and obese insulin-sensitive subjects, and fasting insulin greater than 9.0 mU/l for obese insulin-resistant subjects
- Fasting glucose less than 6.1 mmol/l
- Body temperature below 37.5 0C
- First-degree relative with known type 2 diabetes for obese insulin-resistant subjects
- Weight stable within �b15 kg for less than 3 months before screening
- Fluent in Swedish and able to follow instructions
- Provided consent to participate
You will not qualify if you...
- First-degree relative with known type 2 diabetes for lean or obese insulin-sensitive subjects
- Alcohol intake above 10 units per week or known high alcohol intake less than 10 years prior
- Daily use of cigarettes or frequent daily use of smokeless tobacco that cannot be suspended during study visits
- Regular physical activity at Saltin-Gimby level 4
- Special diets such as Atkins or 5:2 for weight reduction; vegetarian diet accepted if longer than 1 year
- Impaired fasting glucose (venous fasting plasma glucose 6.1-6.9 mmol/l)
- Diagnosis of type 2 diabetes according to ADA criteria
- Ongoing or previous ischemic heart disease treated with platelet inhibitors or non-vitamin-K oral anticoagulants
- Heart failure (NYHA II-IV) or cardiac arrhythmia needing treatment
- Previous cerebral infarction or transient ischemic attack treated with platelet inhibitors or anticoagulants
- Peripheral arterial insufficiency such as claudication
- Hypertension above 170/105 mmHg at screening or requiring more than one class of antihypertensive drugs
- Lipid disorders with fasting serum triglycerides over 5.0 mmol/l or serum cholesterol over 7.5 mmol/l
- Hematologic diseases such as untreated anemia or bleeding disorders
- Renal failure with estimated glomerular filtration rate below 60 ml/min/1.73 m2
- Hypothyroidism with TSH over 4.0 mIE/l and symptoms
- Liver diseases such as hepatitis B, cirrhosis, or elevated AST/ALT over 2 times normal
- Systemic inflammatory diseases except celiac disease, dyspepsia, or IBS
- Chronic bronchitis or COPD with symptoms
- Previous pancreatitis or pancreatic diseases needing treatment
- Stress-induced migraine
- Spinal problems preventing lying down during study
- Drug addiction or psychiatric issues interfering with study
- Medications affecting adipose metabolism not stopped 10 days before study
- Use of beta-blockers
- Antibiotic use within 3 months
- Cancer diagnosed less than 5 years ago
- Physical or lab findings making participation inappropriate
- Pregnancy or intention to become pregnant during study
- Shift work more than once per week affecting circadian rhythm
- Other reasons judged by investigator to make participation inappropriate
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Gothia Forum CTC
Gothenburg, Region Vastra Gotaland, Sweden, SE-413 46
Actively Recruiting
Research Team
P
Per-Anders E Jansson, Prof
CONTACT
V
Vagner R Silva, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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