Actively Recruiting
Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity
Led by Ann & Robert H Lurie Children's Hospital of Chicago · Updated on 2024-08-22
260
Participants Needed
1
Research Sites
227 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study, doctors want to find out more about why people who lose weight often regain the weight that they have lost once they resume a regular diet and whether hormones might play a role in weight regain. The study is divided into two parts, called the meal replacement period and the follow-up period. The meal replacement period will consist of drinking a shake for breakfast and lunch and eating a frozen meal for dinner that is calorie controlled. Individuals will also be asked to eat two servings of fruit and three servings of vegetables each day. The study will provide the shakes and the frozen entrees, participants are asked to supply the fruits and vegetables. Participation in this study will last for up to 35 weeks. There will be 10 in-person visits and 13 visits by phone or over Zoom over the 35 weeks.
CONDITIONS
Official Title
Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 11 and less than 16 years
- Body mass index (BMI) over 30 kg/m² or at the 95th percentile or higher
- Tanner stage 2, 3, or 4
You will not qualify if you...
- Tanner stage 1 or 5
- Previous bariatric surgery
- Use of anti-obesity medications like orlistat, metformin, phentermine, topiramate, combination phentermine/topiramate, liraglutide, or combination naltrexone/bupropion within 3 months before enrollment
- Monogenic or hypothalamic obesity
- Diagnosed polycystic ovary syndrome
- Pregnancy or planning to become pregnant
- Current use of supplemental hormones
- Diagnosed eating disorders including anorexia nervosa, bulimia, or binge eating disorder
- Type 1 or type 2 diabetes
- Treatment with growth hormones
- Thyroid disease or problems
- Cancer diagnosis within the past 10 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ann & Robert H Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
J
Justin Ryder, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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