Study of Adaptive Optics Imaging to Improve Diagnosis and Management of Eye Diseases in People Age 12 and Older

What this Trial Is About

Researchers are studying adaptive optics, a new imaging method, to improve the way retinal diseases are diagnosed, treated, and managed. This observational study includes 350 participants with various eye diseases and 250 healthy volunteers aged 12 and older. The goal is to better detect retinal problems earlier than current methods allow, by comparing images from normal and diseased eyes. Participants will undergo comprehensive eye exams including visual acuity, intraocular pressure checks, pupil dilation, and adaptive optics imaging using specialized instruments at the National Eye Institute Eye Clinic. Additional tests may include perimetry, color vision tests, and electroretinograms involving numbing eye drops and special contact lenses. Imaging and assessments will be repeated as needed during one or more study visits. During their visits, participants will provide medical and eye history, answer questions about medications, and have their pupils dilated for imaging. Adaptive optics imaging requires participants to look steadily into an instrument while images of their retina are captured. Researchers will analyze these images qualitatively and quantitatively to compare healthy and diseased eyes. The study will last up to five years, with ongoing monitoring of image quality and retinal health.

Adaptive Optics Retinal Imaging