Actively Recruiting
Adaptive Optics Imaging in Retinal Disorders
Led by The Hospital for Sick Children · Updated on 2026-04-28
200
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying inherited and acquired retinal disorders to better understand changes in photoreceptors, retinal pigment epithelium, and retinal blood vessels. This observational study uses adaptive optics (AO) technology to visualize retinal structures in living patients and compare them to healthy controls. The study aims to evaluate the effects of various treatments and develop AO imaging as a measure of outcomes in retinal diseases. The study plans to enroll about 200 participants including approximately 175 with retinal diseases and 25 healthy controls. Participants will undergo AO retinal imaging using the rtx1 device, which is non-invasive and uses infrared light to capture high-resolution images of the retina. The imaging will be done at baseline, then repeated at 6 months and 1 year to observe any changes or effects of treatment. Participants will provide medical and family history and have their retinal images taken at scheduled visits. The study measures include quantifying cone photoreceptor density and spacing, retinal pigment epithelium density, and retinal blood flow using software within the AO device. Follow-up imaging compares changes over time to assess disease progression or treatment impact. The total participation includes baseline and two follow-up visits over one year.
CONDITIONS
Brief Title
Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consent provided
- Aged 5 to 70 years
- Diagnosed with a well documented retinal disorder
- Control group: aged 5 to 70 years with normal eye examination
- Control group: patients with strabismus and otherwise normal vision and eye exam
- Control group: patients with unilateral eye diseases such as cataract with a normal fellow eye
You will not qualify if you...
- Unable to maintain a stable seated position
- Uncontrolled eye or head movements such as nystagmus or trembling
- Presence of cataract or any eye opacity that blocks retinal imaging
- Any general disease like neurological conditions affecting vision or retina
- History of previous uveitis, glaucoma, intra-ocular surgery, or photodynamic therapy
- High refractive errors greater than +15D or less than -15D not correctable by AO system
- History of photosensitivity or use of photosensitivity-causing medicines
- Aphakic patients after cataract surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline visit
Participants undergo adaptive optics retinal imaging and related assessments to measure retinal structures and function.
1 visit (in-person)
Duration - Up to 1 year
Participants return for follow-up visits to reimage and assess changes in retinal condition at 6 months and 1 year.
2 visits (in-person) at 6 months and 1 year
Trial Site Locations
Total: 1 location
1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Actively Recruiting
Research Team
A
Ajoy Vincent, MS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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