Using Adaptive Optics Retinal Imaging to Study Inherited and Acquired Retinal Disorders in Patients Aged 5 to 70 Years

What this Trial Is About

Researchers are studying inherited and acquired retinal disorders to better understand changes in photoreceptors, retinal pigment epithelium, and retinal blood vessels. This observational study uses adaptive optics AO technology to visualize retinal structures in living patients and compare them to healthy controls. The study aims to evaluate the effects of various treatments and develop AO imaging as a measure of outcomes in retinal diseases. The study plans to enroll about 200 participants including approximately 175 with retinal diseases and 25 healthy controls. Participants will undergo AO retinal imaging using the rtx1 device, which is non-invasive and uses infrared light to capture high-resolution images of the retina. The imaging will be done at baseline, then repeated at 6 months and 1 year to observe any changes or effects of treatment. Participants will provide medical and family history and have their retinal images taken at scheduled visits. The study measures include quantifying cone photoreceptor density and spacing, retinal pigment epithelium density, and retinal blood flow using software within the AO device. Follow-up imaging compares changes over time to assess disease progression or treatment impact. The total participation includes baseline and two follow-up visits over one year.

Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders