Study of Different Amounts of Aerobic Exercise During Chemotherapy in Adults with Stage II or III Colon Cancer

What this Trial Is About

Researchers are studying how different amounts of aerobic exercise during chemotherapy affect the chemotherapy dose intensity in people who have survived colon cancer. The study focuses on adults with confirmed stage II or III colon cancer who have completed surgery and are starting chemotherapy. The goal is to understand the relationship between exercise dose and chemotherapy delivery among colon cancer survivors. Participants are randomly assigned to one of five groups a control group performing static stretching or one of four aerobic exercise groups with increasing weekly durations of 75, 150, 225, or 300 minutes. The aerobic exercise involves moderate- to vigorous-intensity activity. The study uses adaptive randomization with double masking to compare these different exercise doses against attention control during the chemotherapy period. During the study, participants will be monitored for their chemotherapy relative dose intensity over 12 or 24 weeks. Researchers will assess physical ability, exercise readiness, and collect consent and healthcare professional approvals before participation. The study tracks adherence to exercise prescriptions and evaluates safety and compliance throughout the intervention period. Total participation time corresponds with chemotherapy treatment duration and study assessments.

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer