Actively Recruiting
Add-on Diuretics in Acute Decompensated Heart Failure
Led by Tanta University · Updated on 2026-02-04
66
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to compare the efficacy and safety of empagliflozin, acetazolamide, and metolazone as add-on therapies to loop diuretics in patients with acute decompensated heart failure.
CONDITIONS
Official Title
Add-on Diuretics in Acute Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients older than 18 years
- Hospital admission with clinical diagnosis of acute decompensated heart failure
- At least one clinical sign of volume overload such as edema, ascites confirmed by echography, or pleural effusion confirmed by chest X-ray or echography
You will not qualify if you...
- Type 1 diabetes
- Chronic kidney disease with estimated glomerular filtration rate (eGFR) less than 30 mL/min per 1.73 m² or end-stage kidney failure requiring chronic dialysis
- Systolic blood pressure less than 90 mmHg
- Cardiogenic shock
- Receiving acetazolamide maintenance therapy
- Use of SGLT2 inhibitor, thiazide, or thiazide-like diuretic within 48 hours before randomization
- Heart failure decompensation due to causes needing urgent management such as acute coronary syndrome, unstable arrhythmias, or acute pulmonary embolism
- Pregnant or breastfeeding women
- Moderate to severe anemia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tanta university
Tanta, Egypt
Actively Recruiting
Research Team
D
Dalia A Gomaa, MSc in clinical pharmacy
CONTACT
D
Dalia R El-Afify, Associate professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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