Actively Recruiting
Added Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment
Led by Centre Hospitalier Rouffach · Updated on 2024-02-14
50
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of the study is to determine the predictive value of the neuroendocrine tests TRH-∆∆TSH (thyreoliberin - thyreostimulin) and DST (dexamethasone suppression test) in the subsequent response to rTMS-TBS (repetitive transcranial magnetic stimulation-theta burst stimulation) treatment, defined as at least a 50% decrease in depression score after 20 sessions of rTMS-TBS.
CONDITIONS
Official Title
Added Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Depressive episode diagnosed by DSM-5 criteria
- Age between 18 and 65 years
- Hospitalized with inadequate response to two prior antidepressant treatments
- Hamilton Depression Scale score of 18 or higher at inclusion
- Written informed consent given
- Enrolled in or receiving social security benefits
You will not qualify if you...
- Endocrine disorders
- Contraindications to neuroendocrine tests (allergies to substances used)
- Contraindications to rTMS: cochlear implant, cardiac pacemaker, metal clips/stents/electronic implants near stimulation coil, intracranial hypertension, poorly controlled seizures
- Prior treatment with monoamine oxidase inhibitors or lithium salts within 6 months
- Pregnant or breastfeeding
- Under court protection or deprived of liberty
- Under guardianship or similar legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Rouffach
Rouffach, Alsace, France, 68250
Actively Recruiting
Research Team
M
MIHAELA TOMSA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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