Actively Recruiting
Addiction Potential of Very Low Nicotine Filtered Little Cigars
Led by Ohio State University Comprehensive Cancer Center · Updated on 2025-10-16
50
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how reducing the nicotine content in filtered little cigars can affect the the use of these cigars and lung health in current adult filtered little cigar users. The main question\[s\] it aims to answer are: Are puffing behaviors, appeal/satisfaction, craving suppression, pharmacokinetic effects, and demand similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Are health effects and toxicant exposure similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Participants will attend three study visits at OSU. Each visit would last up to 4 hours. During visits, they will * fill several surveys * provide blood samples * perform breathing tests * complete smoking sessions using either their own cigars or the study cigars.
CONDITIONS
Official Title
Addiction Potential of Very Low Nicotine Filtered Little Cigars
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Regular use of filtered little cigars, cigarillos, little cigars, or small cigars for the past 3 months, smoking at least 8 cigars per month; or cigarette smokers (8 or more days per month for at least 3 months) who have used filtered little cigars or similar cigars before or would consider switching to them if cigarettes were unavailable
- Willing to abstain from all tobacco and nicotine for at least 12 hours before lab sessions
- Willing to bring their own preferred brand of little cigars or similar products to the first study visit
- Able and willing to provide written informed consent
- Able to read and speak English
You will not qualify if you...
- Significant current lung disease such as asthma, COPD, cystic fibrosis, or pulmonary fibrosis (exercise-induced asthma and seasonal allergies treated with inhalers are allowed)
- History of lung cancer diagnosis or treatment
- Serious or uncontrolled kidney, liver, or metabolic diseases
- Cardiac event or distress within the past 3 months
- Unstable or significant psychiatric conditions (stable past conditions allowed)
- Substance use disorders other than nicotine addiction
- Regular use of other tobacco products besides cigarettes more than 10 days per month
- Exclusive use of large or premium cigars
- Frequent use of blunts (most or every time)
- Regular cannabis use more than 10 days per month
- Planning to quit smoking in the next 30 days, currently trying to quit, or quit attempt in the past 30 days
- Pregnant, delivered in the past 12 weeks, breastfeeding, or planning pregnancy
- Inability to perform tests or follow instructions during testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
D
Dharini M Bhammar, PhD, MBBS
CONTACT
T
The Ohio State University Comprehensive Cancer Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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