Addiction Support After Liver Transplant for Alcohol-Related Liver Disease A Study to Reduce Alcohol Relapse and Improve Survival

What this Trial Is About

Researchers are studying liver transplantation in patients with end-stage liver disease caused by Alcohol-Associated Liver Disease AALD. This study evaluates whether adding a specialized addiction intervention after liver transplantation can reduce the rates of alcohol relapse, a common and serious problem that affects long-term survival. The study compares a new approach involving addiction specialists to usual care without such targeted addiction support. Participants are randomly assigned to one of two groups the intervention group receives addiction consultations during hospital stay and follow-up based on their individual risk factors, including motivational interviews and possible medication the control group receives routine transplant center follow-up without systematic addiction specialist involvement. Follow-up visits occur monthly in the first year and bi-monthly in the second year, with addiction referral only if alcohol relapse is detected. The study will monitor participants for two years after their liver transplant hospitalization discharge. Participants will be closely monitored over two years with various assessments including alcohol use relapse timing, tobacco and other substance use, clinical events, liver function tests, alcohol biomarkers, liver fibrosis, cognitive changes, and mortality rates. Researchers will collect detailed data through outpatient visits and laboratory tests to evaluate the effectiveness of the addiction intervention on preventing alcohol relapse and improving long-term outcomes after liver transplantation.

ADDICTOlogical Intervention in LIVEr Transplantation Recipients