Actively Recruiting
Adding Aprepitant to a Multimodal Strategy for the Prevention of Postoperative Nausea and Vomiting in High-risk Outpatient Surgical Patients
Led by Centre hospitalier de l'Université de Montréal (CHUM) · Updated on 2026-03-03
260
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative nausea and vomiting (PONV) are a frequent and debilitating complications after surgery, affecting up to 80% of patients at high risk in the absence of prophylaxis. Despite the rigorous application of the recommendations from the American Society of Anesthesiologists (ASA) at CHUM, a recent local study reveals a prevalence of 25% PONV at home after outpatient surgery. However, the therapeutic options at home remain limited. This study aims to evaluate if the addition of 40 mg aprepitant to a multimodal strategy for preventing PONV improves clinical outcomes in high-risk patients undergoing outpatient surgery.
CONDITIONS
Official Title
Adding Aprepitant to a Multimodal Strategy for the Prevention of Postoperative Nausea and Vomiting in High-risk Outpatient Surgical Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and over requiring outpatient surgery
- High risk of postoperative nausea and vomiting with at least 3 Apfel score factors (female sex; non-smoker; history of postoperative nausea or vomiting or motion sickness; expected opioid use after surgery)
You will not qualify if you...
- Refusal or inability to give consent
- Known or suspected allergy to aprepitant (Emend)
- Use of medications interacting with aprepitant via cytochrome CYP3A4 (pimozide, terfenadine, astemizole, comtadin, or cisapride)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centre hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
Research Team
M
Maxim Roy, MD, FRCPC
CONTACT
V
Vicky Thiffault, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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