Actively Recruiting

Phase 3
Age: 20Years - 50Years
MALE
NCT06274333

Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort

Led by Al-Azhar University · Updated on 2026-01-06

60

Participants Needed

1

Research Sites

135 weeks

Total Duration

On this page

Sponsors

A

Al-Azhar University

Lead Sponsor

B

Benha University

Collaborating Sponsor

AI-Summary

What this Trial Is About

The insertion of a urinary catheter in a patient undergoing a surgical procedure, especially urinary interventions, may lead to catheter-related bladder discomfort (CRBD) with varying degrees of severity during the postoperative period. Paracetamol is a drug with proven efficacy for the management of mild and moderate postoperative pain. Tramadol is a centrally acting, synthetic opioid analgesic with weak opioid agonist properties. It inhibits the detrusor activity by inhibition of type-1 muscarinic (M1) and type-3 muscarinic (M3) receptors. Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, with analgesic, sedative, anxiolysis, sympatholytic, and sedative properties, is a very useful associated agent for general anesthesia.

CONDITIONS

Official Title

Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort

Who Can Participate

Age: 20Years - 50Years
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Age from 20 to 50 years
  • Male gender
  • American Society of Anesthesiologists (ASA) physical status I or II
  • Scheduled for percutaneous nephrolithotomy (PCNL) surgery
Not Eligible

You will not qualify if you...

  • History of psychotic illnesses
  • Current opioid use
  • Bladder obstruction
  • Benign prostatic hyperplasia
  • Overactive bladder, defined as urinating 3 or more times at night or 8 or more times within 24 hours

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Neveen Kohaf

Cairo, Cairo Governorate, Egypt, 11865

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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