Actively Recruiting
Adding Of Naxitamb In Induction Therapy For High Risk Neuroblastoma
Led by Guangzhou Women and Children's Medical Center · Updated on 2024-08-28
64
Participants Needed
1
Research Sites
451 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To explore the efficacy of adding anti-GD2 immunotherapy (Naxitamab) at the stage of induction chemotherapy for newly diagnosed high risk neuroblastoma patients. To investigate wether anding Naxitamab in the induction phase will improve the response rate at the end of induction therapy and further improve the overall survival rate.
CONDITIONS
Official Title
Adding Of Naxitamb In Induction Therapy For High Risk Neuroblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children with newly diagnosed stage 4 neuroblastoma aged over 18 months regardless of biology
- Children aged 12-18 months with stage 4 neuroblastoma and unfavorable biology (MYCN amplification, poor histopathology, or DNA index = 1)
- Children with MYCN amplification regardless of age or biology in stage 4
- Children with stage 3 neuroblastoma with MYCN amplification or over 18 months with poor histopathology
- Children with stage 2A/2B neuroblastoma with MYCN amplification
- Patients must be aged 12 months or older and 21 years or younger at diagnosis
You will not qualify if you...
- Infants younger than 1 year old
- Children aged 12-18 months with stage 4 neuroblastoma but favorable biology
- Stage 3 neuroblastoma patients with favorable biology
- Patients who received immunosuppressive treatment (excluding local steroids) within 4 weeks before enrollment
- Patients currently receiving any investigational drug
- Patients with medical conditions interfering with study participation or results, including malabsorption syndrome, mental illness, substance abuse
- Patients with significant unrelated serious medical conditions that may interfere with treatment or increase toxicity
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Guangzhou Women And Children's Medical Center
Guanzhou, Guangdong, China, 510000
Actively Recruiting
Research Team
W
Wenyue Si, Bachelor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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