Actively Recruiting
Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
Led by UMC Utrecht · Updated on 2026-05-05
174
Participants Needed
3
Research Sites
343 weeks
Total Duration
On this page
Sponsors
U
UMC Utrecht
Lead Sponsor
D
Dutch Pancreatic Cancer Group (DPCG)
Collaborating Sponsor
AI-Summary
What this Trial Is About
A randomized controlled trial, nested within an existing prospective cohort (Dutch Pancreatic Cancer Project; PACAP) according to the 'trials within cohorts' (TwiCs) design in which the effect of additional local ablative therapy compared to current standard of care alone, on survival after recurrence in patients with isolated local pancreatic ductal adenocarcinoma (PDAC) recurrence. The most important secondary endpoint is quality of life. Other secondary endpoints are treatment response, acute and late toxicity, overall survival, progression-free survival, local progression-free survival, distant metastases free survival and reasons for non-eligibility or exclusion.
CONDITIONS
Official Title
Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participation in the PACAP cohort with written informed consent for being randomized in future studies
- Isolated local recurrence after primary PDAC resection
- Minimum age of 18 years
You will not qualify if you...
- Distant metastases
- Expected lifespan less than 3 months
- Ineligibility for MRI or CT according to the protocol of the local radiology department
- Highly selective cases with resectable, isolated local recurrence eligible for re-resection without need for systemic or local ablative induction therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Amsterdam University Medical Center, VUmc
Amsterdam, North Holland, Netherlands, 1081 HV
Actively Recruiting
2
Erasmus University Medical Center
Rotterdam, South Holland, Netherlands, 3015 GD
Actively Recruiting
3
University Medical Center Utrecht
Utrecht, Utrecht, Netherlands, 3584 CX
Actively Recruiting
Research Team
M
M. P.W. Intven, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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