Actively Recruiting
Additive Anti-inflammatory Action for Aortopathy & Arteriopathy
Led by Nanjing Medical University · Updated on 2026-02-09
10000
Participants Needed
34
Research Sites
782 weeks
Total Duration
On this page
Sponsors
N
Nanjing Medical University
Lead Sponsor
B
Beijing Anzhen Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is essential for an appropriate management of AAS. Twenty Chinese cardiovascular centers have collaborated to create a multicenter observational registry (named Chinese registry of Additive Anti-inflammatory Action for Aortopathy \& Arteriopathy \[5A\]), with consecutive enrollment of adult patients who underwent surgery for AAS that was started on Jan 1, 2016 and will be ended on December 31, 2040. Specially, the impact of inflammation and anti-inflammatory strategies on the early and late adverse events are investigated. Primary outcomes are severe systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), Sequential Organ Failure Assessment (SOFA) scores at 7 days following this current surgery. Secondary outcomes are SISR, 30-day mortality, operative mortality, hospital mortality, new-onset stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.
CONDITIONS
Official Title
Additive Anti-inflammatory Action for Aortopathy & Arteriopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older.
- Diagnosis of Acute Aortic Syndrome, including aortic dissection, penetrating aortic ulcer, or intramural hematoma.
- Symptoms started within 14 days before surgery.
- Received medical therapy, open surgical, endovascular, or hybrid repair for AAS.
- Any major cardiac surgery performed together with AAS surgery, such as coronary artery bypass grafting or carotid artery replacement.
- Patient or guardian agrees to participate in the study.
You will not qualify if you...
- Younger than 18 years.
- Symptoms started more than 14 days before surgery.
- AAS caused by traumatic or iatrogenic injury.
- Declined participation in the registry and follow-up.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 34 locations
1
Beijing Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Actively Recruiting
2
Chongqing Hospital of Jiangsu Provincial People's Hospital
Chongqing, Chongqing Municipality, China
Actively Recruiting
3
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
Actively Recruiting
4
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
Actively Recruiting
5
QianXiNan People's Hospital
Xingyi, Guizhou, China
Actively Recruiting
6
The Second Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Actively Recruiting
7
The Third Affiliated Hospital of Soochow University
Changzhou, Jiangsu, China
Actively Recruiting
8
Suqian Hospital of of Nanjing Medical University
Suqian, Jiangsu, China
Actively Recruiting
9
Dongtai People's Hospital
Yancheng, Jiangsu, China
Actively Recruiting
10
Subei People's Hospital of Jiangsu Province
Yangzhou, Jiangsu, China, 225001
Actively Recruiting
11
the Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 300088
Actively Recruiting
12
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Actively Recruiting
13
Shanghai DeltaHealth Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
14
Shanxi Cardiovascular Hospital
Taiyuan, Shanxi, China
Actively Recruiting
15
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Actively Recruiting
16
The Seventh Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
Actively Recruiting
17
The Friendship Hospital of Yili Kazak Autonomous Prefecture
Yining, Xinjiang, China
Actively Recruiting
18
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
Actively Recruiting
19
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
20
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
Actively Recruiting
21
Beijing Anzhen Hospital Capital Medical University
Beijing, China
Actively Recruiting
22
Beijing Chaoyang Hospital
Beijing, China
Actively Recruiting
23
the First Affiliated Hospital of Bengbu Medical College
Bengbu, China
Actively Recruiting
24
Xiangya Hospital Central South University
Changsha, China
Completed
25
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Actively Recruiting
26
the First Affiliated Hospital of Guilin Medical College
Guilin, China
Actively Recruiting
27
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China, 210029
Actively Recruiting
28
Nanjing First Hospital, Nanjing Medical University
Nanjing, China
Actively Recruiting
29
the Affiliated Hospital of Qingdao University
Qingdao, China
Completed
30
Shanghai East Hospital Tongji University
Shanghai, China
Completed
31
the First Affiliated Hospital of Shantou University Medical College
Shantou, China
Actively Recruiting
32
Teda International Cardiovascular Hospital
Tianjin, China
Actively Recruiting
33
Tianjin Chest Hospital
Tianjin, China
Actively Recruiting
34
Xiamen Cardiovascular Hospital
Xiamen, China
Completed
Research Team
H
Hong Liu, MD
CONTACT
H
Hai-yang LI, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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