Using Urine Mass Spectrometry to Improve Medication Adherence and Control in Patients with Poorly Controlled Hypertension

What this Trial Is About

Hypertension is a major cause of cardiovascular disease and death, and many patients have uncontrolled blood pressure often due to not taking medications as prescribed. This research aims to study if testing urine for antihypertensive drugs can better detect medication non-adherence in patients with hypertension, including those who recently had a stroke. The study will evaluate whether identifying non-adherence and providing targeted counseling can improve medication use and blood pressure control. The study has three parts first, reviewing urine samples from 200 patients who recently had a stroke to check medication adherence second, enrolling 100 patients with poorly controlled hypertension to assess adherence prospectively and third, counseling participants found to be non-adherent and reassessing them at 3 and 6 months. Urine samples of 50ml will be collected during visits for mass spectrometry analysis to detect medication levels. Participants will attend study visits at enrollment, 3 months, and 6 months, providing urine samples each time. Researchers will measure changes in medication adherence rates and blood pressure, including systolic and diastolic values, over 6 months. The study aims to improve adherence and blood pressure control, potentially reducing healthcare visits and serious cardiovascular events.

Addressing Medication Non-adherence in Patients With Poorly Controlled Hypertension Using Urine Mass Spectrometry