Actively Recruiting
A Randomized, Single-blind Study of Adductor Canal Block With IPACK Infiltration Versus Adductor Canal Block Alone for Post-Operative Pain and Opioid Use in Patients Undergoing HTO, DFO, or TTO
Led by NYU Langone Health · Updated on 2026-02-25
100
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of combining an adductor canal block with an IPACK infiltration versus using an adductor canal block alone on post-operative pain and opioid use in patients undergoing high tibial osteotomy (HTO), distal femoral osteotomy (DFO), or tibial tubercle osteotomy (TTO). This randomized, single-blind, single-center study focuses on improving pain management after these orthopedic surgeries. Participants are randomly assigned to receive either an adductor canal block (ACB) combined with an IPACK block or an adductor canal block alone. The ACB involves injecting 15 mL of 0.25% Bupivacaine under ultrasound guidance to block the saphenous nerve, while the IPACK block administers 20 mL of 0.25% Bupivacaine into the space between the popliteal artery and the knee capsule. These treatments are given around the time of surgery to assess their impact on post-operative pain and opioid consumption. During the study, researchers will measure opioid use during the first 24 hours after surgery as the primary outcome. Secondary outcomes include pain scores reported by patients at various time points up to six months after surgery, length of stay in the post-anesthesia care unit, and physical function scores related to knee injury and osteoarthritis. Participants will be monitored for safety, pain control, and recovery progress throughout the post-operative period and follow-up visits up to six months after surgery.
CONDITIONS
Brief Title
Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following HTO/DFO/TTO
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients between 18 and 75 years of age
- Patients undergoing high tibial osteotomy (HTO), distal femoral osteotomy (DFO), or tibial tubercle osteotomy (TTO)
- American Society of Anesthesiologists (ASA) physical status classification I or II
You will not qualify if you...
- Patients younger than 18 or older than 75 years
- Patients with multi-ligament knee injury
- Patients undergoing concomitant cartilage procedure or anterior cruciate ligament reconstruction (ACLR)
- Patients with history of chronic pain using opioids for 3 months or longer
- Patients allergic to oxycodone
- Patients with diagnosed or self-reported cognitive dysfunction
- Patients with neurologic disorders affecting pain sensation
- Patients with history of drug or alcohol abuse
- Patients unable to understand or follow instructions
- Patients with severe liver disease, kidney failure, congestive heart failure, or significant heart disease
- Patients allergic or contraindicated to study medications or procedures
- Patients with body mass index (BMI) over 45
- Patients unable to comply with all study procedures
- Pregnant patients (assessed by urine pregnancy test before surgery)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment
Duration - Up to 3 hours post-operation
Participants undergo either an adductor canal block with IPACK infiltration or an isolated adductor canal block for post-operative pain management following surgery.
1 surgery and immediate post-operative visit in the Post-Anesthesia Care Unit (PACU)
Duration - 7 days post-operation
Participants are followed for up to 7 days after surgery to assess pain levels and opioid use.
Daily visits or assessments for up to 7 days
Duration - 6 months post-operation
Participants are assessed at 6 months post-operation to evaluate knee function and pain outcomes.
1 follow-up visit at 6 months
Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
Research Team
L
Laith Jazrawi, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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