Study Evaluating Dialysis Efficiency and Patient Outcomes Comparing High and Low Convection Volume Haemodiafiltration and Different Dialysate Sodium Concentrations

What this Trial Is About

This observational study focuses on patients with end stage kidney disease ESKD undergoing haemodialysis HD or haemodiafiltration HDF. It aims to understand differences in middle molecules clearance and patient outcomes between high 23 Litres and low <23 Litres convection volume HDF treatments. The study also evaluates how dialysate fluid sodium concentration 137 vs 140 mmolL affects overhydration volume in patients receiving HD and HDF. Participants are observed in groups based on their treatment type those receiving high or low convection volume HDF and those dialysing with different dialysate sodium concentrations 137 or 140 mmolL. No additional interventions are administered, as this study monitors routine dialysis treatments to assess toxin clearance, fluid status, and sodium balance in real-world settings. Participants will be monitored for 12 months to assess the effect of convection volume and dialysate sodium concentration on middle molecules clearance and patient-reported outcomes such as fatigue and recovery time. Long-term follow-up over 5 years will examine the relationship between middle molecule clearance and major cardiovascular events and hospitalizations. Data collection includes clinical evaluations, patient questionnaires, fluid status measurements, and biochemical markers to comprehensively assess dialysis adequacy and patient health.

Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance