Study of Brain Stimulation Therapy for Children Aged 12 to 17 With ADHD to Improve Inhibitory Control

What this Trial Is About

Children aged 12 to 17 with Attention Deficit Hyperactivity Disorder ADHD are being studied to understand how brain stimulation affects their ability to control impulses. Researchers focus on a brain region called the pre-supplementary motor area pre-SMA, which is known to function abnormally in ADHD. This study evaluates the effects of stimulating this brain area using a technique called Transcranial Magnetic Stimulation TMS to see how it influences measures linked to inhibitory control. Participants will undergo cognitive testing and brain MRI during the first visit. The second visit includes baseline physiological measures using TMS, and a behavioral task called the stop signal task while brain activity is recorded using EEG. After this, participants receive two rounds of intermittent theta burst stimulation iTBS, a special type of repetitive TMS. The first round is randomized to either actual stimulation or a sham placebo version, while the second round is always active stimulation. Following the stimulation, the same tests and measurements are repeated. A third visit, conducted virtually one week later, checks for any side effects. During the study, children complete brain scans, cognitive tests, EEG recordings, and TMS assessments to monitor brain activity and responses to stimulation. Researchers measure specific brain signals and reaction times immediately after each stimulation session to evaluate changes. Safety is monitored during the follow-up virtual visit. The entire process spans at least one week after the stimulation visit, allowing for careful assessment of effects and potential side effects.

ADHD PreSMA Response Inhibition Therapy