Actively Recruiting
ADHD PreSMA Response Inhibition Therapy
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-01-27
40
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
ADHD children have abnormal inhibitory control, meaning they have trouble stopping themselves from doing something they should not do. This ability to control involves an area in the brain called the pre-supplementary motor area (pre-SMA). Scientists have previously shown that the pre-SMA is abnormal in ADHD patients. In this study, we will use Transcranial Magnetic Stimulation (TMS) to stimulate the pre-SMA and determine the effects on measures that are related to inhibitory control.
CONDITIONS
Official Title
ADHD PreSMA Response Inhibition Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of ADHD
- Age between 12 and 17 years
- Stimulant medications allowed but must be stopped 24 hours before and during TMS visits
You will not qualify if you...
- Medical conditions increasing TMS risk, including epilepsy, traumatic brain injury, brain tumor, stroke, intellectual disability, cerebral palsy, neurodegenerative diseases, hearing problems, metallic objects in the head, or other serious conditions
- Any implanted medical devices such as ports, shunts, stimulators, or cochlear implants
- Pregnancy for biological females who are post-menarche, confirmed by urine test
- Hearing impairment or chronic tinnitus
- Clinically significant brain MRI findings
- History of conduct disorder, major depression, bipolar disorder, obsessive compulsive disorder, anxiety disorder, or psychotic disorder
- Use of non-stimulant ADHD medications like alpha2 adrenergic agonists, atomoxetine, or tricyclics
- Use of neuroleptic or antipsychotic medications
- Inability to undergo MRI
- Active or past suicidality or high suicide risk
- Substance abuse or dependence in the past year, except prescribed ADHD medication detected in urine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
Research Team
K
Karlee Migneault, B.A.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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