Actively Recruiting
ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation
Led by University of Minnesota · Updated on 2025-07-09
1125
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new electronic health record (EHR)-based strategy designed to improve adherence to lung-protective ventilation (LPV) for patients requiring mechanical ventilation. This cluster randomized trial involves 10 hospitals classified by size to ensure balanced groups. The study compares patient outcomes before and after implementing the intervention, allowing direct comparison between hospitals using the new ventilator order and those continuing standard care. The intervention consists of a new ventilator order integrated into the EHR, developed using economic behavior theory to ease the ordering process for providers. Key features include automatic calculation of predicted body weight (PBW) based on height, prompts to obtain height if missing, simplified ventilator modes aligned with standard care, reduced redundant information, and improved visualization through cascade orders. The intervention period lasts 9 months, after which the new strategy will be introduced to all hospitals. Participants are patients aged 18 and older who require mechanical ventilation at one of the participating hospitals. Researchers will monitor adherence to lung-protective ventilation over 4 hours as the primary outcome, along with secondary measures such as time spent with specific tidal volume settings over 72 hours. Data collection includes ventilator settings and patient outcomes during the intervention and control periods. The trial runs from July 2025 to July 2026, with no masking or blinding applied.
CONDITIONS
Brief Title
ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 and over
- Requires mechanical ventilation
You will not qualify if you...
- The patient opted out of research
- The ventilator mode ordered does not require a set tidal volume
- Requires ECMO prior to ICU admission
- Data recorded during ECMO use
- Hospitalization was for an elective surgery
- Mechanical ventilation duration was less than 12 hours
- Documentation of Do Not Intubate order
- Height documented as less than 4 feet due to PBW formula limitations
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 72 hours
Participants who require mechanical ventilation are randomized to receive either the current ventilator order or a new ventilator order designed to improve operability and lung-protective ventilation.
Continuous monitoring during mechanical ventilation
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
N
Nick Ingraham, MD, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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