What is the new ventilator order studying for patients on mechanical ventilation?

This study is evaluating a new ventilator order designed to improve how lung-protective ventilation is delivered to patients requiring mechanical ventilation. Researchers want to see if the new electronic health record strategy helps providers follow lung-protective ventilation guidelines better. The study is led by the University of Minnesota and compares outcomes across multiple hospitals.

Who may be eligible for this ventilation clinical trial?

Adults aged 18 and older who require mechanical ventilation may be eligible to participate. The trial includes patients of all genders but excludes those who have opted out of research, have a height less than 4 feet, require ECMO before ICU admission, or have ventilation durations under 12 hours. Please review eligibility criteria for more details.

Is there any cost to participate in this ventilation clinical trial?

Study-related care, including the ventilator order changes and all trial data collection, is provided at no cost. However, personal travel or other expenses related to participation may vary and are not guaranteed to be covered.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

ID06895148

ADHERE-LPV Trial of New Electronic Health Record Ventilator Orders Improving Lung-Protective Ventilation Across 10 Hospitals Randomized Comparison in Adults on Mechanical Ventilation

Led by University of Minnesota · Updated on 2026-07-09

1125

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating a new electronic health record EHR strategy designed to improve adherence to lung-protective ventilation LPV practices among patients requiring mechanical ventilation. This cluster randomized trial involves 10 hospitals, classified by size based on the number of mechanically ventilated patients. Randomization occurs at the hospital level, allowing comparison of outcomes before and after implementing the strategy, as well as between hospitals using the standard ventilator order and those using the new order. The study is led by the University of Minnesota and focuses on improving ventilation care processes. The intervention group implements a new ventilator order developed with behavioral economics principles to reduce cognitive load on providers and enhance order usability. Changes include automatic calculation of predicted body weight PBW based on height, prompts to obtain height if missing, simplified ventilator modes, and improved visualization of orders. The control group continues using the current ventilator order. The intervention period lasts for 9 months before the new strategy is rolled out to all hospitals. Participants are adult patients aged 18 and over who require mechanical ventilation in the participating hospitals. Researchers will collect data on ventilator settings, adherence to LPV principles measured by tidal volume settings over specified periods, and timing to achieve target volumes. Outcomes include the duration patients receive protective tidal volumes and exposure to higher tidal volumes, monitored over 72 hours. The study runs from July 2025 to December 2026, with outcome assessments focusing on ventilation quality within 4 hours and up to 72 hours of mechanical ventilation.

CONDITIONS

Brief Title

ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Aged 18 and over
Requires mechanical ventilation

You will not qualify if you...

Patient opted out of research
Ventilator mode does not require a set tidal volume
Requires ECMO prior to ICU admission
Data during ECMO use
Hospitalization for elective surgery
Mechanical ventilation duration less than 12 hours
Admission code indicates Do Not Intubate
Height documented as less than 4 feet

Research Team

Nick Ingraham, MD, MS

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