Actively Recruiting
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
Led by University of Colorado, Boulder · Updated on 2026-04-28
84
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified due to their potential as circulating biomarkers of adipose tissue health and systemic messengers, regulators and mediators of cardiometabolic health and disease with obesity. The investigators hypothesize that elevated Ad-EVs in adults with obesity will be negatively associated with endothelium-dependent vasodilation. Furthermore, the investigators hypothesize that in adults with obesity, intentional weight loss-induced reduction in circulating Ad-EVs is associated with greater endothelium-dependent vasodilation.
CONDITIONS
Official Title
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- BMI less than 25 kg/m2 and greater than 25 kg/m2 for Phase 1
- BMI greater than 25 kg/m2 for Phase 2
You will not qualify if you...
- Current smoker
- Chronic overt medical conditions such as coronary artery disease, history of heart attack or stroke, cancer, or diabetes
- Alcohol abuse or dependence exceeding 14 drinks per week or more than 4 drinks per day for men, and 7 drinks per week or 3 drinks per day for women
- Stage III hypertension with blood pressure over 160/100 mmHg
- Regular vigorous aerobic/endurance exercise more than 3 times per week for over 30 minutes at high intensity
- Women who are pregnant or breastfeeding
- History of anaphylaxis to betadine, lidocaine, or iodine
- Raynaud's disease
- History of clotting disorders
- Use of blood thinners or clotting medications
- Use of statin medications
- Planned pregnancy in the next 4 to 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Boulder Clinical and Translational Research Center (CTRC)
Boulder, Colorado, United States, 80309
Actively Recruiting
Research Team
J
Jared Greiner, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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