Study of Adipocyte-Derived Extracellular Vesicles and Their Role in Obesity-Related Endothelial Dysfunction Effects of Weight Loss on Circulating Biomarkers and Blood Vessel Health in Adults with Obesity

What this Trial Is About

Researchers are investigating the role of adipocyte-derived extracellular vesicles Ad-EVs in adults with obesity, focusing on their connection to endothelial dysfunction and cardiovascular risks. The study aims to understand if higher levels of Ad-EVs relate to poorer blood vessel function and whether weight loss can reduce Ad-EVs and improve this function. This research is led by the University of Colorado, Boulder, and explores a novel biomarker linked to obesity-related vascular health. The study has two phases. Phase 1 is a cross-sectional comparison between adults of normal weight and those with obesity to assess the association between circulating Ad-EVs and blood vessel function. Phase 2 involves a 12-week weight loss intervention in adults with obesity, where participants follow a hypocaloric diet guided by a nutrition specialist to achieve 6-10% weight loss. Researchers will measure changes in Ad-EVs and blood flow responses before and after the intervention. Participants will attend visits where blood samples will be collected to measure circulating Ad-EVs, and forearm blood flow responses to specific agents will be assessed to evaluate endothelial function. These measurements occur approximately two weeks after starting Phase 1 and about 17 weeks after beginning Phase 2. The study monitors cardiovascular health markers and weight loss effects over time, with total participation lasting through the intervention and assessment periods.

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function