Study of Adipose Tissue Blood Flow Differences in Younger and Older Healthy Adults

What this Trial Is About

Researchers are evaluating how blood flow in fat tissue changes between younger adults aged 18 to 35 and older adults aged 65 to 80 who are healthy. The study aims to find out if basal and nutrient-responsive adipose tissue blood flow differs between these age groups and to identify related molecular and systemic changes. This basic science clinical trial is conducted by the Mayo Clinic and involves healthy volunteers. Participants will undergo several procedures during one visit. They will have a dual x-ray absorptiometry scan, baseline blood tests, and a cardiopulmonary exercise test after fasting overnight. Blood flow in fat tissue will be measured on one side of the abdomen using the xenon washout method, followed by a small fat tissue biopsy. After drinking a sugary drink containing 75 grams of glucose, blood flow measurements and a second biopsy will be done on the opposite side about 30 minutes later. Blood pressure will be monitored during blood flow assessments. Participants will provide informed consent and may undergo a urine pregnancy test if applicable. Researchers will collect blood samples before and after glucose intake and analyze the blood flow in fat tissue at fasting and after nutrient intake. The main outcomes measured are adipose tissue blood flow and genomic changes related to blood flow. The study visit involves detailed testing and lasts for several hours, with continuous monitoring to understand how aging affects fat tissue function.

Adipose Tissue Blood Flow in Aging Humans