Actively Recruiting
Adipose Tissue Blood Flow in Aging Humans to Understand Changes in Fat Tissue Between Younger and Older Adults
Led by Mayo Clinic · Updated on 2026-05-01
24
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating how blood flow in fat tissue changes between younger adults aged 18 to 35 and older adults aged 65 to 80 who are healthy. The study aims to find out if basal and nutrient-responsive adipose tissue blood flow differs between these age groups and to identify related molecular and systemic changes. This basic science clinical trial is conducted by the Mayo Clinic and involves healthy volunteers. Participants will undergo several procedures during one visit. They will have a dual x-ray absorptiometry scan, baseline blood tests, and a cardiopulmonary exercise test after fasting overnight. Blood flow in fat tissue will be measured on one side of the abdomen using the xenon washout method, followed by a small fat tissue biopsy. After drinking a sugary drink containing 75 grams of glucose, blood flow measurements and a second biopsy will be done on the opposite side about 30 minutes later. Blood pressure will be monitored during blood flow assessments. Participants will provide informed consent and may undergo a urine pregnancy test if applicable. Researchers will collect blood samples before and after glucose intake and analyze the blood flow in fat tissue at fasting and after nutrient intake. The main outcomes measured are adipose tissue blood flow and genomic changes related to blood flow. The study visit involves detailed testing and lasts for several hours, with continuous monitoring to understand how aging affects fat tissue function.
CONDITIONS
Brief Title
Adipose Tissue Blood Flow in Aging Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 35 years or 65 to 80 years at the time of the study visit
- Body mass index (BMI) between 20 and 25.0 kg/m2
You will not qualify if you...
- Diagnosed cardiometabolic diseases such as Type 2 diabetes, hypertension, or heart failure
- Taking prescription anticoagulants
- Taking medications or supplements that affect fat tissue metabolism (like statins, thiazolidinediones, niacin, atypical antipsychotics, or fish oil)
- Pregnant or nursing
- Unable to provide written informed consent
- Smoking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including blood tests, exercise testing, and adipose tissue blood flow measurements before and after consuming a 75 gm oral glucose load. Adipose tissue biopsies and blood pressure measurements are performed during this visit.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Mayo Clinic Minnesota
Rochester, Minnesota, United States, 55905
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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