Study of How Bariatric Surgery Affects Fat Storage and Metabolic Health in Adults With or Without Type 2 Diabetes

What this Trial Is About

Researchers are studying the relationship between changes in fat tissue metabolism and the remission of Type 2 Diabetes T2D following bariatric surgery. This study involves adults aged 18 to 65 with or without T2D, divided into two groups to compare metabolic differences after surgery. The primary goal is to understand if improved fat storage contributes to the rapid improvement of liver and heart metabolism after the procedure. Participants will undergo laparoscopic sleeve gastrectomy as the bariatric surgery method. The study includes five visits a screening visit and four detailed metabolic sessions before and after surgery. These sessions involve consuming a liquid meal, receiving stable tracer infusions, and undergoing PET and MRI scans. During one session before surgery, participants receive niacin to assess its effect on fat metabolism. Metabolic sessions occur before surgery, 12 days post-surgery, and one year after surgery. Throughout the study, participants will be monitored during these metabolic visits lasting 9 hours each, involving tracer perfusions, imaging scans, and blood tests. Researchers will measure fat uptake and processing in various tissues, glucose production, insulin secretion, and other metabolic and hormonal responses. The study will track changes from baseline to one year after surgery to understand the metabolic mechanisms related to T2D remission.

Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery