Actively Recruiting
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Led by Université de Sherbrooke · Updated on 2026-02-10
40
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
Sponsors
U
Université de Sherbrooke
Lead Sponsor
I
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Collaborating Sponsor
AI-Summary
What this Trial Is About
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery. All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.
CONDITIONS
Official Title
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 65
- BMI 35 kg/m2
- Diagnosed Type 2 Diabetes according to Diabetes Canada criteria
- Diagnosed non-Type 2 Diabetes according to Diabetes Canada criteria
- Women with a negative serum pregnancy test
You will not qualify if you...
- Treatment with oral contraceptives
- Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker drugs that affect metabolism and cannot be stopped temporarily or have long-lasting effects
- Presence of overt cardiovascular disease, liver or kidney failure, or other uncontrolled medical conditions
- Any contraindication to surgery or to temporarily stopping current medications for diabetes, lipids, or hypertension
- Smoking or drinking more than 2 alcoholic beverages per day
- Any contraindication to MRI
- A Diabetes Remission (DiaRem) score greater than 8
- Participation in a research study with radiation exposure within the last two years
- Pregnant or breastfeeding women
- Weight over 200 kg exceeding MRI and PET/CT scanner limits
- Allergy to eggs
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
centre de recherche du CHUS
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
Research Team
F
Frédérique Frisch
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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