Study of Erythritol Powder Added to Deep Cleaning for Treating Advanced Gum Disease

What this Trial Is About

Researchers are evaluating whether adding erythritol powder during non-surgical periodontal treatment deep cleaning can improve gum health in people with advanced periodontitis stage 3 or 4. The study focuses on individuals with deep gum pockets of 4 mm or more and aims to see if erythritol helps with healing, bleeding, plaque levels, and gum attachment compared to standard treatment alone. The trial is randomized and led by the University of LAquila. Participants receive either standard non-surgical periodontal therapy, which involves scaling and root planing with ultrasonic and manual instruments, or the same treatment combined with sub-gingival air polishing using erythritol powder. Each participant undergoes a single treatment session targeting periodontal pockets of at least 4 mm in depth on non-adjacent teeth. During the study, researchers measure the proportion of gum pockets that successfully close at 2 and 4 months after treatment. They also track bleeding, plaque levels, and gum attachment to assess periodontal health. Factors such as age, sex, smoking status, and diabetes are monitored to understand how they may affect treatment response. Participation involves clinical evaluations and periodontal assessments over the study period ending in late 2025.

Adjunctive Effect of Erythritol on Pocket Closure Rates