Actively Recruiting
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
Led by The Canadian College of Naturopathic Medicine · Updated on 2026-01-23
90
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
Sponsors
T
The Canadian College of Naturopathic Medicine
Lead Sponsor
O
Ottawa Hospital Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a two arm RCT evaluating the effect of intravenous vitamin C versus placebo in patients with incurable non-small cell lung cancer. Participants in both arms will be receiving platinum doublet chemotherapy with or without concurrent immunotherapy as standard care. We plan to enroll 90 patients over 5 years.
CONDITIONS
Official Title
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults (≥18 years of age) with stage IIIB or IV primary non-small cell lung cancer
- Eligible and scheduled for first line platinum-doublet chemotherapy with or without concurrent immunotherapy
You will not qualify if you...
- ECOG status greater than 2
- Received intravenous vitamin C within 6 months prior to randomization
- Biochemical deficiency in G6PD
- Estimated Glomerular Filtration Rate (eGFR) less than 45 mL/min
- Currently taking insulin or warfarin
- History of severe renal dysfunction or hemochromatosis
- Received cytotoxic chemotherapy or immunotherapy within 12 months prior to randomization
- Pregnant or planning pregnancy without being a carrier of the gene for G6PD deficiency
- Currently taking an investigational product or participating in an investigational study within the past 30 days
- Any condition that would prevent participation as judged by the Principal Investigator or delegate
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H8L6
Actively Recruiting
Research Team
D
Dugald Seely, ND, MSc
CONTACT
M
Mark Legacy, BSc, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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