Actively Recruiting
Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis
Led by Sixth Affiliated Hospital, Sun Yat-sen University · Updated on 2026-01-28
650
Participants Needed
1
Research Sites
608 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Adjuvant chemotherapy was unnecessary in pathological stage Ⅱ colorectal cancer following initial treatment of surgery without high risk factors of recurrences. The treatment efficacy of adjuvant chemotherapy for pT1-3N0M0 colorectal cancer following preoperational chemotherapy or chemoradiotherapy remains unclear. Part of clinical local advanced colorectal cancer(cTxN1-2M0), which turn out to be pT0-3N0M0 after preoperational chemotherapy or chemoradiotherapy, might not really need adjuvant chemotherapy due to the down-stage efficacy of the preoperational treatments, or the misleading by lymph nodes false-positive imaging diagnosis.
CONDITIONS
Official Title
Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preoperative clinical tumor stage III (TxN1-2M0) colorectal cancer
- Pathologically confirmed colorectal adenocarcinoma by endoscopic biopsy
- Postoperative pathological stage T0-3N0M0 without high-risk recurrence factors
- Ability to understand and sign written informed consent
You will not qualify if you...
- History of other malignant tumors
- Complications requiring emergency surgery (such as occlusion, sub-occlusion, massive hemorrhage, or abscesses)
- Tumor extension making immediate liver R0 resection impossible
- Non-resectable lymph node metastasis
- American Society of Anesthesiologists (ASA) grade IV or higher and/or ECOG score 2 or higher
- Physical or psychological dependence
- Pregnant or breastfeeding women
- Uncontrolled preoperative infection
- Participation in other clinical trials within 4 weeks
- Other clinical or laboratory conditions deemed unsuitable by investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510655
Actively Recruiting
Research Team
J
Jianping Wang, MD/PHD
CONTACT
J
Jun Huang, MD/PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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