Actively Recruiting

Phase 3
Age: 18Years - 75Years
All Genders
NCT05797467

Adjuvant Chemotherapy Combined With Targeted Therapy or Not in the T3-4N2 Colorectal Cancer Patients

Led by Sixth Affiliated Hospital, Sun Yat-sen University · Updated on 2023-05-24

366

Participants Needed

1

Research Sites

521 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial\] is to compare in resectable stage T3-4N2 colorectal cancer. The main question it aims to answer is: whether the use of targeted therapy in combination with adjuvant chemotherapy is associated with improved disease-free survival (DFS) compared to adjuvant chemotherapy alone.

CONDITIONS

Official Title

Adjuvant Chemotherapy Combined With Targeted Therapy or Not in the T3-4N2 Colorectal Cancer Patients

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Both sexes, aged 18-75 years
  • Pathologically confirmed pT3-4N2 stage colorectal adenocarcinoma after surgery
  • ASA grade less than IV and/or ECOG performance status score 2 or less
  • Fully understand and voluntarily sign the informed consent form for this study
Not Eligible

You will not qualify if you...

  • History of other malignant tumors
  • Severe liver, kidney, cardio-pulmonary, or coagulation dysfunction or underlying diseases that prevent chemotherapy
  • Allergy to any study components
  • Severe uncontrollable recurrent infections or other severe diseases
  • Factors affecting study results or causing early withdrawal such as alcoholism, drug abuse, serious diseases including mental illness, or severe lab abnormalities
  • Emergent surgery due to intestinal obstruction, perforation, bleeding, etc.
  • History of severe mental illness
  • Pregnant or lactating women
  • Other clinical or laboratory conditions deemed inappropriate by investigators

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

The Sixth Affiliate Hospital of Sun Yat-Sen University

Guangzhou, Guangdong, China

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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