Actively Recruiting
Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy
Led by yair lotan · Updated on 2026-03-30
650
Participants Needed
1
Research Sites
761 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective study to determine if the adjuvant use of Curcumin improves recurrence-free survival.
CONDITIONS
Official Title
Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men aged 30 to 80 years at diagnosis with a life expectancy of at least 3 years
- Status post radical prostatectomy for histologically confirmed adenocarcinoma of the prostate
- Pathologically confirmed T1 to T3 disease without lymph node or metastatic disease
- Patients considered low risk for pelvic lymph node or metastatic disease per NCCN or AUA guidelines, including Gleason 6 or 7 (T2 disease) and PSA less than 20
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2
- Adequate kidney and liver function and bone marrow reserve (serum creatinine <2 mg/dL, bilirubin ≤1.5 mg/dL, ANC ≥1.5 x 10^3/uL, platelets ≥50 x 10^3/uL, hemoglobin ≥10 g/dL)
- Focally positive surgical margins allowed
- No plan to receive adjuvant hormone or radiation therapy
- PSA undetectable at enrollment
You will not qualify if you...
- More than 3 months have passed from surgery to study enrollment
- T3b or T4 disease or node positive disease
- Macroscopic residual disease after surgery
- Hormone therapy received before surgery
- History of gallbladder problems, gallstones, or biliary obstruction unless cholecystectomy performed
- Radiation therapy as primary treatment after surgery
- INR value greater than 1.5
- AST or ALT levels at least twice the upper limit of normal
- Use of antiplatelet or anticoagulant agents, except low-dose aspirin (81mg) with close observation
- History of gastric or duodenal ulcers or untreated acid-related disorders
- Currently taking Curcumin and unwilling to stop or planning to take Curcumin during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
C
Corey Nixon
CONTACT
C
Catherine Robinson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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