Actively Recruiting
Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress
Led by Iowa State University · Updated on 2023-08-24
80
Participants Needed
1
Research Sites
291 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the extent to which a single session of light to moderate intensity exercise performed within 30 minutes after receiving either the initial dose of COVID-19 mRNA vaccine may modify the immune response to vaccination, and identify potential underlying mechanisms using gene expression and metabolite analysis. A secondary goal is to establish whether psychosocial factors are associated with immune response to vaccination. Participants will be randomized to either a 90-minute light to moderate intensity exercise session or daily routine as usual (no exercise) after receiving their initial COVID-19 mRNA vaccine. If assigned to exercise, the exercise will begin within 30 minutes after receiving the vaccine and will consist of a brisk walk and/or jog supervised by study personnel. Blood will be collected from participants prior the initial dose, two weeks after the initial dose, one week after the second dose if the individual receive the two-dose vaccine regiment or one month after the initial dose if the individual receives a one-dose vaccine regimen, and three, six, and 12 months following the initial dose. . Side effects will be measured for three days post-vaccination. Antibody and cell-mediated immune response to the vaccine will be measured in blood samples. Gene expression profiles will be analyzed by single cell RNA sequencing. Serum metabolites will be assessed to align with immune measures. Participants will be asked to complete surveys to measure physical activity history, psychosocial stress, resilience, and depression. The hypotheses of this study are: 1) a single session of exercise which take place shortly after receiving either the initial dose or the booster dose of COVID-19 will increase antibody and T cell response to the vaccine and will be associated with differentially expressed genes and an altered metabolite profile, and 2) higher levels of reported stress, and lower levels of resilience will be associated with a reduced antibody and T cell response to the vaccine.
CONDITIONS
Official Title
Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to donate a small amount of blood
- Planning to receive an initial mRNA COVID-19 vaccine
- Between 18 and 64 years of age
- Regularly participate in exercise two or more times per week, including at least one session lasting 50 minutes or more, or walk three or more times per week with at least one session lasting 50 minutes or more
- Can safely perform 90 minutes of light to moderate intensity exercise (walk, walk/jog, or jog) based on exercise participation guidelines
You will not qualify if you...
- Currently pregnant
- Weigh less than 110 pounds
- Have any condition that would affect safe exercise or prevent receiving the mRNA COVID-19 vaccine
- Taking medication that significantly affects immune response or have an immune disorder
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Iowa State University
Ames, Iowa, United States, 50011
Actively Recruiting
Research Team
M
Marian Kohut, PhD
CONTACT
K
Kaitlyn Holden, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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