Effect of Single Session Exercise and Psychosocial Factors on Immune Response to Initial COVID-19 mRNA Vaccine

What this Trial Is About

This research aims to assess how a single session of light to moderate exercise performed within 30 minutes after receiving the initial COVID-19 mRNA vaccine dose may influence the immune response to vaccination. It also explores whether psychosocial factors like stress, resilience, or depression affect the vaccine's immune response. Participants will be adults aged 18 to 64 who regularly exercise and plan to receive their initial mRNA COVID-19 vaccine dose. Participants are randomly assigned to either a supervised 90-minute exercise session or to continue their usual daily routine without exercise after vaccination. The exercise involves brisk walking or jogging, adjusted for each participant's fitness level and monitored by heart rate and perceived exertion. Those in the control group are asked to avoid exercise on vaccination day. Blood samples and psychosocial surveys will be collected before vaccination and at multiple points up to 12 months afterward to study antibody levels, T cell responses, gene expression, and metabolites. During the study, participants will complete surveys about physical activity and psychosocial health, record side effects for three days post-vaccination, and provide blood samples at specified intervals: before vaccination, two weeks after, one week after the second dose or one month after a single dose, and at three, six, and twelve months. Researchers will analyze immune responses, gene activity, and metabolites, comparing exercise and control groups. Side effects and psychosocial factors will also be monitored to understand their relationship with immune responses over a year-long follow-up.

Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress