Actively Recruiting
Adjuvant Radiotherapy in High Risk Locally Advanced DTC
Led by Fudan University · Updated on 2026-02-27
124
Participants Needed
1
Research Sites
359 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a phase III randomized controlled clinical trial on the role of adjuvant radiotherapy in high-risk locally advanced differentiated thyroid cancer. Patients who meet the inclusion criteria were randomly assigned 1:1 to either the experimental group (adjuvant radiotherapy+RAI) or the control group (RAI), with LRFS as the primary endpoint of the study.
CONDITIONS
Official Title
Adjuvant Radiotherapy in High Risk Locally Advanced DTC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient voluntarily agrees and signs informed consent
- Age 14 years or older, but younger than 80 years
- Diagnosed with differentiated thyroid cancer by histopathology
- Underwent total or near total thyroidectomy surgery
- Surgery did not achieve complete tumor removal; residual tumor volume less than 2cm3 if resection was R2
- Main organ functions are normal
- Able to comply and cooperate with follow-up visits
You will not qualify if you...
- Previous radiation therapy to the head and neck
- Thyroid cancer with poorly differentiated or undifferentiated components
- Presence of distant metastasis
- Prior treatment with 131I
- Previous or current targeted therapy, immunotherapy, or chemotherapy
- Active other malignant tumors within 5 years, except certain cured local tumors
- Pregnant or lactating women
- Other physical illnesses affecting ability to receive treatment
- Serious illnesses or conditions that could force study termination
- Claustrophobia preventing radiation therapy
- Deemed unsuitable by attending physicians
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fudan Univeristy Shanghai Cancer Center
Shanghai, China
Actively Recruiting
Research Team
N
Naisi Huang, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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