Actively Recruiting
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
Led by Canadian Cancer Trials Group · Updated on 2026-05-12
393
Participants Needed
108
Research Sites
340 weeks
Total Duration
On this page
Sponsors
C
Canadian Cancer Trials Group
Lead Sponsor
C
Canadian Cancer Clinical Trials Network
Collaborating Sponsor
AI-Summary
What this Trial Is About
This protocol tests de-escalated adjuvant treatment in patients with POLE-mutated or p53wt/NSMP (p53 wildtype/no specific molecular profile) early-stage endometrial cancer (EC). Patients may be enrolled in one of two sub-studies * EN10.A/RAINBO BLUE: POLE-mutated EC * EN10.B/TAPER: p53 wildtype / NSMP EC
CONDITIONS
Official Title
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must have had surgery consisting of hysterectomy and bilateral salpingo-oophorectomy with no visible residual disease
- Histologically confirmed Stage I to III endometrial carcinoma of any specified subtype
- Eastern Cooperative Group (ECOG) performance status of 0, 1, or 2
- HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible
- Age 18 years or older
- Patient consent obtained according to local and regulatory requirements
- Ability and willingness to complete patient-reported outcome questionnaires in English, French, or a validated language
- Accessibility for treatment and follow-up at the participating center
- Protocol treatment must begin within 10 weeks of surgery
You will not qualify if you...
- Prior neoadjuvant chemotherapy for current endometrial cancer diagnosis
- Prior pelvic radiation
- History of other malignancies except treated carcinoma in-situ, non-melanoma skin cancer, or other tumors with no evidence of disease for 5 or more years
- Clinical evidence of distant metastasis by pre- or post-surgical imaging
- Documented positive surgical margin
- Documented positive peritoneal washings if performed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 108 locations
1
Alaska Womens Cancer Care
Anchorage, Alaska, United States, 99508
Actively Recruiting
2
University of Arizona Cancer Center
Tucson, Arizona, United States, 85719
Actively Recruiting
3
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
4
Huntington Memorial Hospital
Pasadena, California, United States, 91105
Actively Recruiting
5
Sutter Medical Center Sacramento
Sacramento, California, United States, 95816
Actively Recruiting
6
UCHealth University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
7
AdventHealth Porter
Denver, Colorado, United States, 80210
Actively Recruiting
8
University of Miami School of Medicine
Miami, Florida, United States, 33136
Actively Recruiting
9
Sarasota Memorial Hospital - Venice
N. Venice, Florida, United States, 34275
Actively Recruiting
10
Florida Cancer Specialists - Sarasota Downtown
Sarasota, Florida, United States, 34236
Actively Recruiting
11
First Physicians Group-Sarasota
Sarasota, Florida, United States, 34239
Actively Recruiting
12
Sarasota Memorial Hospital
Sarasota, Florida, United States, 34239
Actively Recruiting
13
Sarasota Memorial Health Care Centre
Sarasota, Florida, United States, 34243
Actively Recruiting
14
Florida Cancer Specialists - Venice Pinebrook
Venice, Florida, United States, 34275
Actively Recruiting
15
Grady Health System
Atlanta, Georgia, United States, 30303
Actively Recruiting
16
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
17
Piedmont Hospital
Atlanta, Georgia, United States, 30309
Actively Recruiting
18
Emory University Hospital Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
19
Emory Saint Josephs Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
20
Emory Decatur Hospital
Decatur, Georgia, United States, 30033
Actively Recruiting
21
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
22
Northwestern Medicine Orland Park
Orland Park, Illinois, United States, 60462
Actively Recruiting
23
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Actively Recruiting
24
Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, United States, 46260
Actively Recruiting
25
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, United States, 40202
Actively Recruiting
26
Norton Suburban Hospital and Medical Campus
Louisville, Kentucky, United States, 40207
Actively Recruiting
27
University Medical Center New Orleans
New Orleans, Louisiana, United States, 70112
Actively Recruiting
28
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States, 02114
Actively Recruiting
29
Baystate Medical Center
Springfield, Massachusetts, United States, 01199
Actively Recruiting
30
UMass Memorial Medical Centre
Worcester, Massachusetts, United States, 01605
Actively Recruiting
31
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
32
Nebraska Methodist Hospital
Omaha, Nebraska, United States, 68114
Actively Recruiting
33
Womens Cancer Center of Nevada
Las Vegas, Nevada, United States, 89106
Actively Recruiting
34
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, United States, 08080
Actively Recruiting
35
Mount Sinai Chelsea
New York, New York, United States, 10011
Actively Recruiting
36
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
37
Upstate Cancer Center Radiation Oncology at Oswego
Oswego, New York, United States, 13126
Actively Recruiting
38
State University of New York
Syracuse, New York, United States, 13210
Actively Recruiting
39
Upstate Cancer Center at Hill Radiation Oncology
Syracuse, New York, United States, 13210
Actively Recruiting
40
Upstate Cancer Center at Verona
Verona, New York, United States, 13478
Actively Recruiting
41
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
42
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
43
Duke Womens Cancer Care Raleigh
Raleigh, North Carolina, United States, 27607
Actively Recruiting
44
Case Western Reserve University
Cleveland, Ohio, United States, 44106
Actively Recruiting
45
Ohio State University Comprehensive
Columbus, Ohio, United States, 43210
Actively Recruiting
46
UH Seidman Cancer Center
Mentor, Ohio, United States, 44060
Actively Recruiting
47
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
48
Providence Portland Medical Centre
Portland, Oregon, United States, 97213
Actively Recruiting
49
Providence Saint Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
50
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
51
Paoli Memorial Hospital
Paoli, Pennsylvania, United States, 19301
Actively Recruiting
52
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
53
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, United States, 19090
Actively Recruiting
54
Lankenau Medical Center
Wynnewood, Pennsylvania, United States, 19096
Actively Recruiting
55
Women and Infants Hospital
Providence, Rhode Island, United States, 02905
Actively Recruiting
56
M.D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
57
Farmington Health Centre
Farmington, Utah, United States, 84025
Actively Recruiting
58
University of Utah Sugarhouse Health Centre
Salt Lake City, Utah, United States, 84106
Actively Recruiting
59
Huntsman Cancer Institute University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
60
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
61
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405
Actively Recruiting
62
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22908
Actively Recruiting
63
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
64
Swedish Medical Center First Hill
Seattle, Washington, United States, 98122
Actively Recruiting
65
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States, 54301
Actively Recruiting
66
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
67
South Western Sydney Local Health District
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
68
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
69
Calvary Mater Newcastle Hospital
Waratah, New South Wales, Australia, 2298
Actively Recruiting
70
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
71
Mater Research Institute South Brisbane
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
72
Monash Medical Centre
Clayton, Victoria, Australia, 3168
Actively Recruiting
73
Frankston Hospital
Frankston, Victoria, Australia, 3199
Actively Recruiting
74
The Royal Women's Hospital
Parkville, Victoria, Australia, 3053
Actively Recruiting
75
Canberra Hospital
Garran, Australia, ACT 2605
Actively Recruiting
76
Royal Brisbane and Womens Hospital
Herston, Australia, 4029
Actively Recruiting
77
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
78
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
79
BCCA - Kelowna
Kelowna, British Columbia, Canada, V1Y 5L3
Actively Recruiting
80
BCCA - Prince George
Prince George, British Columbia, Canada, V2M 7E9
Actively Recruiting
81
BCCA - Vancouver
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
82
BCCA - Victoria
Victoria, British Columbia, Canada, V8R 6V5
Actively Recruiting
83
Royal Victoria Regional Health Centre
Barrie, Ontario, Canada, L4M 6M2
Actively Recruiting
84
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8V 5C2
Not Yet Recruiting
85
London Health Sciences Centre Research Inc.
London, Ontario, Canada, N6A 5W9
Actively Recruiting
86
Trillium Health Partners - Credit Valley Hospital
Mississauga, Ontario, Canada, L5M 2N1
Actively Recruiting
87
Odette Cancer Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
88
University Health Network
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
89
CHUM-Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
90
The Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
91
CIUSSS de l'Estrie - Centre hospitalier
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
92
Centre Leon Berard
Lyon, Auvergne-Rhône-Alpes, France, 69008
Actively Recruiting
93
Institut Gustave-Roussy
Villejuif, FR, France, 94805
Actively Recruiting
94
Institut Universitaire du Cancer de Toulouse - IUCT
Toulouse, Occitanie, France, 31100
Actively Recruiting
95
Groupe Hospitalier Diaconesses Croix Saint-Simon
Paris, France, 75012
Actively Recruiting
96
ASST Spedali Civili Brescia
Brescia, Italy, 25123
Actively Recruiting
97
ASST Lecco
Lecco, Italy, 23900
Actively Recruiting
98
European Institute of Oncology
Milan, Italy, 20141
Actively Recruiting
99
Policlinico Umberto I, Universita Sapienza
Rome, Italy, 00161
Actively Recruiting
100
Radiotherapiegroep
Arnhem, Gelderland, Netherlands, 6815AD
Actively Recruiting
101
Maastro clinic (Maastricht UMC)
Maastricht, Limburg, Netherlands, 6229ET
Actively Recruiting
102
Catharina ziekenhuis
Eindhoven, North Brabant, Netherlands, 5623 EJ
Actively Recruiting
103
MC Haaglanden
The Hague, South Holland, Netherlands, 432
Actively Recruiting
104
Leiden University Medical Center (LUMC)
Leiden, Netherlands, 2333ZA
Actively Recruiting
105
Erasmus Medical Center (EMC)
Rotterdam, Netherlands
Actively Recruiting
106
Auckland City Hospital
Auckland, New Zealand, 1023
Actively Recruiting
107
Christchurch Hospital
Christchurch, New Zealand, 8140
Actively Recruiting
108
Oslo University Hospital
Oslo, Ullernchausseen 70, Norway, 0379
Actively Recruiting
Research Team
W
Wendy Parulekar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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