Actively Recruiting
Adolescent Outcomes of Post-operative Opioid EXposure
Led by Sharon Levy · Updated on 2026-03-18
20000
Participants Needed
5
Research Sites
168 weeks
Total Duration
On this page
Sponsors
S
Sharon Levy
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associated with risk factors for opioid use disorder (ROUD) in the 12 months following major surgery with opioid exposure among adolescents aged 12-17. Participants will be asked to complete electronic surveys pre- and post-operatively and approve the collection of peri-operative data from the Electronic Medical Record to assess correlations.
CONDITIONS
Official Title
Adolescent Outcomes of Post-operative Opioid EXposure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescents aged 12 to 17 years scheduled for surgery with a high likelihood of requiring opioid pain medicine for at least 48 hours after surgery
- Adolescents able and willing to provide assent and have a parent or caregiver willing to provide consent
- Parent or legal guardian of an eligible adolescent
- Parent or legal guardian willing and able to provide written informed consent
You will not qualify if you...
- Adolescents prescribed opioids in the last 2 years for chronic medical pain
- Adolescents with chronic medical conditions needing ongoing opioid treatment like sickle cell disease, arthritis, or cancer
- Adolescents without a willing caregiver to participate
- Adolescents unable to speak or read English at a 4th-grade level
- Adolescents currently in custody of youth services, jail/prison, or with pending legal actions preventing participation
- Adolescents in custody of child welfare services or living with foster families
- Adolescents who are pregnant or parenting
- Adolescents or parents reporting a diagnosis of opioid use disorder or treatment with medications for it
- Adolescents enrolled in other opioid or pain management intervention studies
- Parents or caregivers who cannot speak or read English or Spanish at a 4th-grade level
- Parents or caregivers currently incarcerated
- Parents or caregivers in physical or mental distress preventing study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Not Yet Recruiting
2
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States, 33701
Not Yet Recruiting
3
Boston Childrens Hopsital - Division of Addiction Medicine
Boston, Massachusetts, United States, 02115
Actively Recruiting
4
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Not Yet Recruiting
5
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
Research Team
S
Sharon Levy, MD, MPH
CONTACT
J
Joesph Cravero, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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