Actively Recruiting
ADRC Clinical Cohort (Alzheimer's Disease)
Led by Duke University · Updated on 2025-08-24
500
Participants Needed
1
Research Sites
318 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment, or a dementia diagnosis. Initial data including demographics, medical and family history, physical exam, and neuropsychological testing will be obtained. Participants will be asked to contribute a blood sample, a urine sample, a cerebrospinal fluid sample, and undergo a MRI scan. The cohort ages 45 to 80 will be seen yearly until death to evaluate medical status, undergo neuropsychological testing and possibly collect additional samples or undergo additional imaging. All data will be de-identified and stored by the ADRC. The purpose of this study is to examine normal cognition, mild cognitive impairment and Alzheimer's disease and related dementias (ADRD) as people get older. The investigators also hope to be able to assess risk factor information of the role of genes and environmental exposures (for example health conditions, diet, and medications) in Alzheimer's disease and related disorders (ADRD) and other conditions of aging. The biological samples collected in the study will create a repository. A repository is a collection of blood and tissue samples from people with certain diseases and conditions. For the purpose of this research, the investigators hope to help researchers learn more about Alzheimer's disease and related disorders and other conditions of aging.
CONDITIONS
Official Title
ADRC Clinical Cohort (Alzheimer's Disease)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 25 and 80 years
- Ability to read at a 6th grade level or higher
- History of academic achievement and/or employment sufficient to exclude intellectual disability
- Signed informed consent given by the participant or legal representative
- Willingness to have an MRI and lumbar puncture or PET scans as an alternative
- For participants aged 45 to 80, having a study partner who agrees to participate and meets reading and intellectual criteria
You will not qualify if you...
- Having a clinically relevant or unstable neurological disorder such as multiple head injuries, stroke, multiple sclerosis, or Parkinson's disease
- Having a clinically relevant or unstable psychiatric disorder
- History of alcoholism or drug dependency/abuse within the past 2 years
- GAD-7 score greater than 9 and/or PHQ-8 score greater than 9
- Uncontrolled medical conditions that pose a significant medical risk
- Contraindications or intolerance to 3T MRI including implanted devices
- History of malignancy treated or untreated within the past 60 months, except certain localized nonmalignant tumors and skin cancers
AI-Screening
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Trial Site Locations
Total: 1 location
1
Duke University
Durham, North Carolina, United States, 27705
Actively Recruiting
Research Team
R
Rachel Dewees, MSW
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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