DukeUNC Alzheimers Disease Research Center Clinical Cohort for Adults Ages 25 to 80 with Normal Cognition, Mild Cognitive Impairment, or Dementia

What this Trial Is About

Researchers are establishing a clinical cohort for the DukeUNC Alzheimers Disease Research Center to study adults aged 25 to 80. The group includes people with normal cognition, mild cognitive impairment, or dementia related to Alzheimers disease and other dementias. The study aims to understand how age, sex, genetics, and environmental factors affect these conditions and to create a repository of biological samples for further research. Participants aged 25 to 44 with normal cognition and those aged 45 to 80 with varying cognitive status will undergo baseline visits that include medical history, physical exams, neuropsychological testing, blood and urine collection, lumbar puncture or PET scans, retinal imaging, and MRI. The older group will have a study partner and annual follow-ups to update medical information, repeat testing, and possibly collect more samples or imaging until death or withdrawal. Throughout the study, participants and their study partners will provide data on cognition, behavior, and health through yearly assessments. A consensus committee reviews each case at baseline and annually to confirm diagnoses. All collected data and biological samples are coded, stored securely, and may be shared with other research centers while protecting participant privacy. The study duration is approximately five years with ongoing monitoring and data collection.

ADRC Clinical Cohort (Alzheimer's Disease)