What is this trial studying for nasal bleeding during nasotracheal intubation?

This trial is studying whether xylometazoline nasal drops or adrenaline nasal packing better reduce nasal bleeding during nasotracheal intubation in patients having oromaxillofacial surgery. Researchers aim to understand which treatment may help manage bleeding risks in this surgical setting. The study is sponsored by the Shaheed Mohtarma Benazir Bhutto Institute of Trauma.

Who may be eligible for this nasal bleeding clinical trial?

Adults aged 18 to 60 years who are scheduled for elective oromaxillofacial surgery and have normal airway assessment scores may be eligible. Both males and females can participate. People with nasal abnormalities, bleeding disorders, or uncontrolled medical conditions are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this nasal bleeding clinical trial?

Study-related care, including the study treatments and all trial visits, is provided at no cost. However, personal travel or other expenses may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Phase 2

Phase 3

Age: 18Years - 60Years

All Genders

ID06801522

Comparing Xylometazoline Nasal Drops and Adrenaline Nasal Pack to Reduce Nasal Bleeding During Nasotracheal Intubation in Adults Undergoing Elective Oro-Maxillofacial Surgery

Led by Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Updated on 2025-01-30

Participants Needed

Research Sites

8 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are comparing the effects of xylometazoline nasal drops and adrenaline nasal packing on nasal bleeding during nasotracheal intubation in participants undergoing elective oromaxillofacial surgeries. The trial aims to determine which of these two treatments better reduces nasal bleeding during the procedure. This study includes participants aged 18 to 60 years with specific health criteria to ensure safety and accuracy. Participants are randomly assigned to one of two groups. One group receives 0.1% xylometazoline nasal drops, administered as 3 to 5 drops in the selected nostril 15 minutes before surgery. The other group receives adrenaline nasal packing, where a gauze soaked in adrenaline is placed inside the nostril 15 minutes before surgery and removed after 7 to 10 minutes. Both groups undergo nasotracheal intubation under general anesthesia with careful monitoring. Throughout the study, participants will have vital signs monitored, including blood pressure, heart rate, ECG, and oxygen saturation. An experienced anesthesiologist will perform the procedures and record the incidence and severity of nasal bleeding during intubation and extubation. Data will be analyzed to compare bleeding outcomes between groups while considering factors like age, gender, and medical history. Participation lasts through the surgical procedure and immediate recovery monitoring.

CONDITIONS

Brief Title

Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation

Who Can Participate

Age: 18Years - 60Years

All Genders

Eligibility Criteria

You may qualify if you...

ASA physical status 1 and 2
Age between 18 and 60 years
Mallampati score 1 or 2
Any gender
Scheduled for elective oromaxillofacial surgery

You will not qualify if you...

Lack of consent
Anticipated difficult airway
Receiving anticoagulant therapy
History of nasal surgery, trauma, polyp, or obstruction
History of repeated nosebleeds
Uncontrolled hypertension, diabetes, pregnancy, or cardiac or cerebral events history

Research Team

Dr Sidra Javed Consultant Anaesthetist, MBBS, FCPS, PAIN FELLOW

Dr Mirza Shahzad Baig Consultant Anaesthetist, MBBS, MCPS, FCPS

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