Actively Recruiting
Led by CHU de Reims · Updated on 2024-06-13
196
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are investigating the occurrence of vascular complications in patients with type 1 diabetes who were part of the DIABAGE study, which originally took place between 2015 and 2017. This study focuses on evaluating new vascular events after at least five years of follow-up and understanding the role of Advanced Glycation End products (AGEs) in predicting these complications. The study is observational and conducted at Reims University Hospital. Participants from the original DIABAGE study will be invited to join this continuation study. Assessments will occur during their regular follow-up visits and may involve a short hospital stay. Evaluations include clinical examinations, biological tests, and investigations for chronic complications such as eye exams, blood pressure indexes, electrocardiograms, and possibly coronary artery calcium scoring. Additionally, skin auto-fluorescence will be measured to assess tissue AGEs using the AGE-Reader device. During the study, researchers will measure the incidence of new microvascular and macrovascular complications. They will also analyze the relationship between initial and later AGE levels in tissues and how these relate to blood sugar control measured by HbA1c over time. Participants can expect regular health evaluations as part of their usual care, with specific tests to monitor vascular health and AGE levels, helping researchers understand long-term risks in type 1 diabetes.
CONDITIONS
Advanced Glycation Products and Vascular Complications in Type 1 Diabetes
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day or week of hospitalization depending on the patient
Participants undergo clinical examination and biological check-ups as part of their usual follow-up during a short hospitalization. Additional tests may include fundus examination, systolic pressure indexes, electrocardiogram, Coronary Artery Calcium score evaluation, and skin auto-fluorescence measurement using the AGE-Reader.
1 visit (in-person)
Duration - At least 5 years
Participants are observed for the incidence of vascular complications and correlation of AGE measurements over at least 5 years of follow-up.
Total: 1 location
1
Chu Reims
Reims, France, 51092
Actively Recruiting
S
Sara BARRAUD, Dr.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Alpha M Diallo, Stéphane Jaisson, Romain Barriquand...
https://pubmed.ncbi.nlm.nih.gov/35779209