Study of Advanced HIV Disease in Adults During Their First Six Months of Antiretroviral Therapy in Zambia

What this Trial Is About

Researchers are studying advanced HIV disease AHD among adults in Zambia who are starting or restarting antiretroviral therapy ART. The study aims to understand the characteristics, care, and outcomes of clients diagnosed with AHD during their first six months on ART, a period when risks of disengagement from care and death are highest. This observational study collects data to help the Zambia Ministry of Health and partners improve treatment guidelines and interventions for AHD patients. The study involves several groups a prospective cohort of adults newly screened for AHD, a hybrid cohort of adults screened in the previous year, an inpatient cohort of adults hospitalized for AHD management, and a provider cohort of health workers involved in AHD care. Participants will be enrolled based on ART initiation status and AHD screening, with data collected from medical records, surveys, interviews, and focus groups. Data collection includes retrospective and prospective periods, covering up to 12 months before and after enrollment. Participants will undergo clinical record reviews and complete surveys and interviews about their care experiences and socioeconomic status. Healthcare providers at study sites will also provide input through surveys and interviews. Researchers will measure outcomes such as retention in care and viral suppression at 6 and 12 months, inpatient characteristics, guideline adherence, and costs. The study will monitor participants during their first six months on ART, with some follow-up extending to 12 months, to better understand and support AHD clients in Zambia.

Advanced HIV Disease During the First Six Months on Antiretroviral Therapy in Zambia