Actively Recruiting
Advanced Therapeutics in Rheumatoid Arthritis (RA)
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-11-29
144
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
L
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor
A
Academic Medical Organization of Southwestern Ontario
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will evaluate the retention rates of two advanced therapies, Tumour Necrosis Factor (TNF) and Janus kinase inhibitor (JAK) in the treatment of adults with Rheumatoid Arthritis (RA) over a two year period. It will also examine the ability to embed a clinical trial in a clinical situation using an electronic medical record (EMR).
CONDITIONS
Official Title
Advanced Therapeutics in Rheumatoid Arthritis (RA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with rheumatoid arthritis who meet criteria for advanced therapy through usual care
- Active rheumatoid arthritis with 5 or more swollen joints
- Seropositive for rheumatoid arthritis
- Presence of joint erosions
- Failure of methotrexate, hydroxychloroquine, and sulfasalazine
- Failure of leflunomide
- 18 years of age or older
- Able to provide informed consent
- Able to attend regular follow-up visits
You will not qualify if you...
- Contraindications to etanercept or tofacitinib
- Active serious infection
- Active tuberculosis
- Multiple sclerosis
- Current cancer
- History of lymphoma
- Previous use of advanced therapy including biologics or JAK inhibitors
- Younger than 18 years
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rheumatology Clinic, St. Joseph's Health Care
London, Ontario, Canada, N6A 4V2
Actively Recruiting
Research Team
J
Janet E Pope, MD MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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