Actively Recruiting
Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms
Led by The University of Texas Health Science Center at San Antonio · Updated on 2026-02-11
24
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
A
Alzheimer's Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Participants will be asked to participate in this research study of a device that creates transcranial direct current stimulation (tDCS). The researchers hope to learn if 30 minute sessions of transcranial direct current stimulation (tDCS) improve such a mood or feelings in people with Alzheimer's Disease. This study involves the use of an investigational device called a tDC stimulator. "Investigational" means that the device has not yet been approved by the U.S. Food \& Drug Administration (FDA) for treating Alzheimer's Disease. This study will help find out what effects, good and/or bad, this has. The safety of this device in humans has been tested in prior research studies; however, some side effects may not yet be known.
CONDITIONS
Official Title
Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand and willingly sign informed consent
- Age 60 years or older
- Diagnosis of possible or probable Alzheimer's Disease or mild cognitive impairment due to Alzheimer's with supporting biomarker evidence
- Clinical Dementia Rating of 0.5 (MCI) with biomarker evidence or 1-2 (mild to moderate dementia) as determined by the study physician
- Presence of any affective symptom such as depression, anxiety, irritability, or apathy with a Neuropsychiatric Inventory Questionnaire total severity score of 10 or higher
- Have an eligible caregiver willing to be present during stimulation sessions and assist with questionnaires
- Ability to speak and read English
- Stable medication doses for at least one month
- Access to reliable broadband internet
- Caregiver is an adult unpaid helper with adequate cognitive, reading, writing, hearing, and verbal skills to assist and provide collateral information
You will not qualify if you...
- Unstable medical conditions that could affect safety or data quality (e.g., unstable angina, uncontrolled diabetes or hypertension, advanced cancer)
- History of serious psychiatric disorders such as bipolar disorder, schizophrenia, or manic depression
- History of epilepsy
- Presence of metallic objects in the brain or skull that interfere with stimulation
- Risk of suicidal behavior or active suicidal ideation with intent or plan in the past 3 months
- Unwillingness or medical contraindication preventing MRI scans at baseline and during week 2
- Participation in other therapeutic clinical trials
- Caregivers who do not meet all inclusion criteria
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
T
Thiago Macedo e Cordeiro, MD, MSc
CONTACT
A
Antonio L Teixeira, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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