Developing a Wearable Device to Noninvasively Measure Insulin Levels in Sweat for Better Nutrition and Health Monitoring

What this Trial Is About

Researchers are investigating a wearable device designed to noninvasively monitor insulin levels through sweat. Insulin is an important hormone that controls blood sugar and energy use, and its imbalance is linked to conditions like diabetes and obesity. By tracking insulin outside the body, this study aims to improve personalized nutrition and health management, offering a new way to understand individual responses to food without blood draws or lab tests. The study involves developing and testing a wearable sensor that stimulates sweat and measures insulin rapidly. Participants will receive a standardized liquid meal containing whey protein, maltodextrin, and sunflower oil. During the study visits, sweat and blood samples will be collected over several hours, using a device on the forearm to gather sweat and a microneedle patch to sample fluids beneath the skin. These samples will help compare insulin levels across different body fluids. Participants will visit the research center after fasting and undergo various health assessments, including body composition scans, walking tests, and muscle function evaluations. Blood samples will be drawn via a catheter, and sweat and skin fluid will be collected while participants rest for up to nine hours. Questionnaires about health and well-being will also be completed. The main goal is to measure insulin and related proteins over time to understand how well the wearable sensor works and how sweat insulin relates to blood insulin levels.

Advancing Precision Nutrition: Wearable Technology for Noninvasive Insulin Monitoring