Actively Recruiting
Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial
Led by Vanderbilt University Medical Center · Updated on 2026-01-12
19480
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and reduce PONV rates in adult patients who have planned surgery with general anesthesia. The main aim is to improve PONV, establishing a scalable Clinical Decision Support (CDS) Tool for personalized PONV prevention. The primary hypothesis is that, compared with standard care, the Anesthesia Workflow-Driven Clinical Decision Support Tool for Personalized PONV Prevention will be associated with a significant improvement in the rate of appropriate administration of PONV prophylaxis and a significant decrease in the incidence of PONV. This study will evaluate a new clinical decision support (CDS) tool designed to improve how and when PONV prevention strategies are used. Unlike traditional tools that provide generic, one-time alerts, this new system is integrated into the electronic health record (EHR) and delivers timely, targeted reminders to anesthesia providers at key moments during a patient's surgical care-such as before surgery begins, after anesthesia is given, and before the patient wakes up. These alerts are based on each patient's individual risk for PONV and are intended to support, not replace, clinical judgment. The study will use a crossover design over 12 months, alternating between periods when the tool is active and when it is not. The goal is to determine whether this time-sensitive, workflow-integrated tool can lead to better adherence to best practices and improved patient outcomes.
CONDITIONS
Official Title
Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Planned surgery with general anesthesia using endotracheal intubation or laryngeal mask airway
- Have zero or more risk factors for PONV, including history of motion sickness or postoperative nausea and vomiting, non-smoker status, female sex, inhalation anesthesia longer than 1 hour, undergoing high-risk surgery (cholecystectomy, laparoscopy, gynecologic), or perioperative opioid use
- Operating room anesthesia providers caring for eligible patients are included
You will not qualify if you...
- ASA physical status 6, including organ procurement
- Patients expected to go directly to the intensive care unit intubated after surgery
- Surgery types excluded: electroconvulsive therapy, intubation only cases, labor epidurals, transesophageal echocardiography (TEE)/cardioversion
- Surgery duration less than 30 minutes
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
Research Team
M
Miklos Kertai, M.D., Ph.D.
CONTACT
G
Gail Mayo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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