Actively Recruiting
Led by Vanderbilt University Medical Center · Updated on 2026-01-12
19480
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating whether a new clinical decision support (CDS) tool integrated into the electronic health record can improve the prevention of postoperative nausea and vomiting (PONV) in adults undergoing planned surgery with general anesthesia. The study aims to see if this tool increases the appropriate use of PONV prevention and lowers the rate of PONV compared to standard care. The trial uses a repeated crossover design over 12 months to test the tool's impact on clinical practice and patient outcomes. The intervention involves the AW-D Clinical Decision Support Tool, which delivers automated reminders to anesthesia providers at key times during surgery, such as before surgery starts, after anesthesia induction, and before the patient wakes up. These alerts are personalized based on each patient's risk factors for PONV and serve as reminders rather than mandates. The study alternates between periods when the tool is active and when it is not, including washout and control phases. Participants will be adult patients undergoing general anesthesia with planned surgery. Researchers will monitor how often PONV prevention medications are given appropriately during surgery and track the incidence of PONV within three hours after surgery. They will also measure the length of stay in the post-anesthesia care unit (PACU). The study involves no direct intervention on patients beyond standard care and data collection. The total participation duration varies with each surgical case and immediate postoperative period.
CONDITIONS
Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Perioperative period (intraoperative and immediate post-anesthesia)
Participants undergo surgery with general anesthesia and may receive reminders for best practice antiemetic medication administration through the clinical decision support tool during the perioperative period.
1 perioperative period with automated notifications during surgery
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
M
Miklos Kertai, M.D., Ph.D.
G
Gail Mayo
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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Ellen G Stallings, Jonathan P Wanderer, Mark Balavage...
https://pubmed.ncbi.nlm.nih.gov/41667172