Advancing Suicide Intervention Strategies for Teens (ASSIST): study protocol for a multisite randomised controlled trial.
Molly Adrian, Elizabeth McCauley, Robert Gallop...
https://pubmed.ncbi.nlm.nih.gov/38086585Actively Recruiting
Phase Not Applicable
Age: 11Years - 17Years
All Genders
Healthy Volunteers
ID05078970
Advancing Suicide Intervention Strategies for Teens During High Risk Periods
Led by Seattle Children's Hospital · Updated on 2025-11-14
306
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Seattle Children's Hospital
Lead Sponsor
N
Nationwide Children's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating strategies to improve the management of suicide risk in adolescents aged 11 to 17 who are experiencing suicidal thoughts or behaviors. The study aims to compare two specific behavioral interventions, Safety Planning Intervention with follow-up (SPI+) and Collaborative Assessment and Management of Suicidality (CAMS), against usual care. The goal is to develop evidence supporting treatments that can be widely adopted, maintained with quality, and have lasting impact on preventing suicidal events. The study involves three groups: one receiving usual care which includes crisis prevention planning and referrals; one receiving SPI+, a brief intervention with weekly follow-ups between 4 and 8 sessions focusing on recognizing suicidal crisis triggers and creating personalized safety plans; and one receiving CAMS, a problem-focused treatment targeting the reasons behind suicidal thoughts with 4 to 8 sessions. Both SPI+ and CAMS are structured interventions designed to engage adolescents and clinicians in collaborative treatment planning. Participants and their parents will be assessed at baseline and multiple follow-up points over 12 months, including 2 weeks, 1 month, 2 months, 6 months, and 12 months. Assessments will cover demographics, suicidal behaviors and thoughts, self-injury, treatment use, risk perception, sleep, family relationships, and social experiences. The primary outcome is the occurrence of suicidal events at 12 months. Safety and treatment integrity will be monitored throughout, with the study conducted under the oversight of Seattle Children's Hospital.
CONDITIONS
Brief Title
Advancing Suicide Intervention Strategies for Teens During High Risk Periods
Who Can Participate
Age: 11Years - 17Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Provision of signed and dated informed consent form
- Youth aged 11 to 17 years
- Endorse suicidal ideation and/or behavior
- Admitted to acute care (emergency, inpatient medical, or inpatient psychiatric) due to suicidality
You will not qualify if you...
- Presence of psychosis, intellectual disability, autism spectrum disorder, or eating disorder with unstable vital signs
- Limited English proficiency interfering with ability to complete study assessments
AI-Screening
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Approximately 4 to 8 weeks
Participants receive one of three interventions: Safety Planning Intervention+ (SPI+), Collaborative Assessment and Management of Suicidality (CAMS), or Treatment As Usual. SPI+ and CAMS involve weekly behavioral therapy sessions, with 4 to 8 sessions aimed at reducing suicidal crises. Treatment As Usual follows typical acute care protocols without alteration by the study.
Weekly visits for 4 to 8 weeks
Follow-up
Duration - Up to 12 months
Participants and their parents complete study assessments to monitor suicidal ideation, suicide attempts, and other behavioral and social factors at multiple timepoints after treatment.
Visits at 2 weeks, 1 month, 2 months, 6 months, and 12 months after treatment starts
Trial Site Locations
Total: 2 locations
1
Nationwide Children's
Columbus, Ohio, United States, 43205
Actively Recruiting
2
Seattle Children's
Seattle, Washington, United States, 98115
Actively Recruiting
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Research Team
M
Molly Adrian
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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