Actively Recruiting
Adverse Adolescent Pathways to Substance Use
Led by University of North Carolina, Chapel Hill · Updated on 2025-05-18
180
Participants Needed
1
Research Sites
331 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anxiety and their legal caregiver will be recruited from clinical and community sources. Procedures: Youth participants will complete several questionnaires and interviews, undergo neuroimaging while performing cognitive tasks, and have their heart rate and skin conductance monitored during a mildly stressful task. Caregivers will complete several questionnaires.
CONDITIONS
Official Title
Adverse Adolescent Pathways to Substance Use
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Aged 12 to 14 years old
- Report symptoms of anxiety
- Able to understand and sign assent, with parent consent in English
- Meet hearing and vision requirements
- Substance use naive
You will not qualify if you...
- Has any foreign metal objects or implants that cannot be removed
- Diagnosed with psychosis or severe emotional disturbance
- Used alcohol, tobacco, or marijuana more than 3 times
- Pregnant or self-reports pregnancy (cannot participate in stress test or MRI)
- Taking medications that alter heart function (e.g., beta blockers)
- Current or past treatment with antipsychotic medication
- History of head injury with loss of consciousness over 5 minutes
- Planning to get non-removable metal braces
- Intellectual functioning below IQ 70
- History of significant central nervous system disorder affecting brain imaging
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The University of North Carolina at Chapel Hill School of Medicine
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
A
Aysenil Belger, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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