Actively Recruiting
Adversity, Brain and Opioid Use Study
Led by University of Michigan · Updated on 2025-12-12
185
Participants Needed
1
Research Sites
168 weeks
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.
CONDITIONS
Official Title
Adversity, Brain and Opioid Use Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Right handed
- Able to give informed consent
- Normal or corrected-to-normal vision and hearing
- For OUD group: Diagnosis of OUD and currently receiving buprenorphine for opioid therapy
- Free from illicit substance use for at least 2 weeks for OUD group
- Stable dose (more than 3 months) of prescribed psychiatric medications or sleep aids allowed
- For BUP control group: Taking buprenorphine for chronic pain without Substance Use Disorder
- For Healthy group: Not taking buprenorphine and free of psychiatric or major medical conditions
You will not qualify if you...
- Significant medical or neurologic conditions such as stroke, seizures, multiple sclerosis
- Actively suicidal
- Contraindication for MRI
- Inability to tolerate small, enclosed spaces without anxiety
- History of schizophrenia, bipolar disorder, learning disability, attention deficit disorder, or pervasive developmental disorder
- Use of substances or medications that interfere with study measures
- Unable to provide informed consent
- Prior participation in similar learning and memory studies at this lab
- Unable to fit comfortably in MRI scanner due to body size limits (specific height and weight restrictions)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
A
Aml Almamri
CONTACT
M
Madeline Vincent
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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