Actively Recruiting
AERIAL Trial: Antiplatelet Therapy in Heart Transplantation
Led by Ottawa Heart Institute Research Corporation · Updated on 2026-05-06
135
Participants Needed
3
Research Sites
400 weeks
Total Duration
On this page
Sponsors
O
Ottawa Heart Institute Research Corporation
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cardiac allograft vasculopathy is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. The research team is investigating whether early antiplatelet therapy post heart transplant can prevent the development of CAV. This study will determine the feasibility of a large multicenter randomized placebo-controlled trial to answer this question.
CONDITIONS
Official Title
AERIAL Trial: Antiplatelet Therapy in Heart Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Heart transplant
- Age 18 years or older
- Able to provide informed consent
You will not qualify if you...
- Allergy or known intolerance to aspirin
- Allergy or known intolerance to clopidogrel
- Intracranial hemorrhage within 14 days
- Bleeding disorder
- Platelet count less than 50 x 10^9/L
- History of aspirin-related gastrointestinal bleeding or ulcers
- Non-cardiac indication for antiplatelet therapy
- Anticoagulation treatment longer than 3 months
- Allergy to iodinated contrast
- Unable to undergo coronary angiography due to low kidney function (glomerular filtration rate 30 mL/min/1.73 m2 or less) for non-dialysis patients
- Unable to undergo coronary angiography due to unsuitable vascular access
- Combined solid organ transplantation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
St.Pauls Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
2
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
3
Toronto General Hospital UHN
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
Research Team
S
Sharon Chih
CONTACT
H
Heather Ross
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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