Actively Recruiting
Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine
Led by University of Sao Paulo · Updated on 2026-04-28
100
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood. This randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session of pain neuroscience education, or a control group, which will receive recommendations for unsupervised physical activity at home. Outcomes related to migraine-related disability, self-reported symptoms, sensory sensitivity, and musculoskeletal function will be assessed at baseline and after the intervention period. Questionnaires will also be collected at a 6-month follow-up. The results of this study may contribute to the development of accessible and low-risk non-pharmacological treatment strategies for people with migraine.
CONDITIONS
Official Title
Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged between 18 and 48 years
- Diagnosed with migraine by a neurologist specialized in headaches using International Classification of Headache Disorders criteria
- Headache frequency between 3 and 8 days per month to ensure treatment adherence
You will not qualify if you...
- Having any other type of headache besides migraine
- Medical conditions affecting sensitivity or autonomic function, such as peripheral neuropathies or severe neurological diseases
- Conditions that prevent physical activity, including severe musculoskeletal injuries or cardiovascular diseases
- Premature ovarian failure
- Regular physical exercise within the past year
- Body Mass Index above 30.0
- Smoking or use of drugs affecting sensitivity and heart regulation, like beta-blockers
- Abuse of medications used to abort headaches
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ribeirão Preto Medical School - University of São Paulo (FMRP-USP)
Ribeirão Preto, São Paulo, Brazil, 14049-900
Actively Recruiting
Research Team
A
Amanda Rodrigues, PhD student
CONTACT
D
Débora Bevilaqua Grossi, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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