Actively Recruiting
Influence of Aerobic Exercise on Sensory Perception, Musculoskeletal and Psychosocial Alterations in Patients With Migraine
Led by University of Sao Paulo · Updated on 2026-04-28
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Migraine is a neurological disorder that causes significant disability and affects sensory processing, musculoskeletal function, and psychosocial health. Researchers are evaluating how combining supervised aerobic exercise with pain neuroscience education compares to general physical activity recommendations in women aged 18 to 48 diagnosed with migraine. The study aims to better understand the effects on sensory perception, musculoskeletal changes, and migraine-related symptoms. Participants will be randomly assigned to one of two groups. The intervention group will attend a single pain neuroscience education session followed by supervised aerobic exercise on a treadmill three times a week for 16 weeks, with exercise intensity tailored to each person's heart rate reserve. The control group will receive guidance to increase physical activity independently at home, aiming for 10,000 steps daily or at least 150 minutes weekly, without supervision or structured education during the same 16-week period. Participants will undergo assessments before and after the 16-week intervention, including migraine-related disability, sensory sensitivity, self-reported symptoms, quality of life, psychosocial factors, and musculoskeletal function using questionnaires and physical tests. A follow-up at six months will collect self-reported outcomes. Researchers will monitor adherence, and the findings may help develop accessible, low-risk non-drug treatment options for migraine.
CONDITIONS
Brief Title
Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged between 18 and 48 years
- Diagnosed with migraine by an experienced neurologist specialized in headaches according to International Classification of Headache Disorders criteria
- Headache frequency between 3 and 8 days per month to ensure treatment adherence
You will not qualify if you...
- Presence of any other type of concurrent headache
- Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies and severe neurological diseases
- Conditions preventing physical activity, including severe musculoskeletal injuries and cardiovascular diseases
- Premature ovarian failure
- Regular physical exercise within the past year
- Body Mass Index (BMI) above 30.0
- Smokers or users of drugs affecting sensitivity and cardiac modulation (e.g., beta-blockers)
- Abuse of abortive medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 16 weeks
Participants in the intervention group attend supervised aerobic exercise sessions three times per week for 16 weeks, combined with a single pain neuroscience education session. Participants in the control group receive physical activity recommendations to be followed at home during the same period.
Supervised group: Approximately 48 exercise sessions plus 1 education session; Control group: Monthly check-ins
Duration - Approximately 2 weeks
Participants complete self-reported outcome measures to assess migraine-related disability and other factors at 6 months after the intervention period.
1 follow-up visit (in-person or remote)
Trial Site Locations
Total: 1 location
1
Ribeirão Preto Medical School - University of São Paulo (FMRP-USP)
Ribeirão Preto, São Paulo, Brazil, 14049-900
Actively Recruiting
Research Team
A
Amanda Rodrigues, PhD student
D
Débora Bevilaqua Grossi, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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