Down syndrome.
Stylianos E Antonarakis, Brian G Skotko, Michael S Rafii...
https://pubmed.ncbi.nlm.nih.gov/32029743Actively Recruiting
Led by Riphah International University · Updated on 2025-04-24
22
Participants Needed
1
Research Sites
2 weeks
Total Duration
Down syndrome is a genetic condition caused by an extra copy of chromosome 21, affecting about 1 in 800 newborns worldwide. This research aims to compare the effects of aerobic exercise alone versus aerobic exercise combined with a low calorie diet on reducing body fat and improving body mass index (BMI) in overweight and obese children with Down syndrome. The study focuses on children aged 8 to 16 years who have a BMI at or above the 85th percentile, representing overweight or obesity status. The trial includes two groups: one group will participate in aerobic exercise combined with a low calorie diet following an intermittent fasting plan, while the other group will do aerobic exercise without any specific diet changes. The aerobic exercise involves warm-up and cool-down sessions, with the diet consisting of fasting periods increasing over 12 weeks. The study is randomized and conducted over a total duration of 10 months, with a sample size of 22 participants. Participants will be assessed using a digital weight scale and BMI calculator at the start and at 12 weeks. Additional evaluations include waist circumference, aerobic fitness via a 6-minute walk test, skin-fold measurements, perceived exertion scales, and food frequency questionnaires. The study monitors changes in adiposity and BMI to provide insights into the best approach for weight management in children with Down syndrome. Data will be analyzed using SPSS software, and all participants will be supervised closely throughout the trial.
CONDITIONS
Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants undergo aerobic exercise, with one group also following a low calorie diet involving intermittent fasting, to evaluate effects on adiposity and BMI.
Weekly visits for up to 12 weeks
Total: 1 location
1
Jannat Arshad
Lahore, Punjab Province, Pakistan, 01234
Actively Recruiting
I
Imran Amjad, PhD
M
Muhammad Asif Javed, MS-PT
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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